Minor histocompatibility antigen
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides .
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Minor histocompatibility antigen H13
HM13: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Belongs to the peptidase A22B family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.23.-; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Protease
Chromosomal Location of Human Ortholog: 20q11.21
Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum membrane; lysosomal membrane; membrane; rough endoplasmic reticulum
Molecular Function: aspartic endopeptidase activity, intramembrane cleaving; peptidase activity; protein binding; protein homodimerization activity; ubiquitin protein ligase binding
Biological Process: membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; membrane protein proteolysis; protein homotetramerization; signal peptide processing
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