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NAD-dependent protein deacylase

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.

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NAD-dependent protein deacylase

Also known as NAD-dependent protein deacylase (Regulatory protein SIR2 homolog 5).
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.

NAD-dependent protein deacylase 1

Also known as NAD-dependent protein deacylase 1 (Regulatory protein SIR2 homolog 1).
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

NAD-dependent protein deacylase 2

Also known as NAD-dependent protein deacylase 2 (Regulatory protein SIR2 homolog 2).
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

NAD-dependent protein deacylase 4

Also known as NAD-dependent protein deacylase 4 (Regulatory protein SIR2 homolog 4).
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

NAD-dependent protein deacylase Sir2

Also known as NAD-dependent protein deacylase Sir2 (Regulatory protein SIR2 homolog).
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

NAD-dependent protein deacylase sir-2.2

Also known as NAD-dependent protein deacylase sir-2.2 (Regulatory protein SIR2 homolog 2).
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

NAD-dependent protein deacylase sir-2.3

Also known as NAD-dependent protein deacylase sir-2.3 (Regulatory protein SIR2 homolog 3).
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

NAD-dependent protein deacylase Sir2A

Also known as NAD-dependent protein deacylase Sir2A (Regulatory protein SIR2 homolog A).
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance. Can ADP-ribosylate both histones and itself. May also have a role in telomeric end protection.

NAD-dependent protein deacylase SIR2rp2

Also known as NAD-dependent protein deacylase SIR2rp2 (Regulatory protein SIR2 homolog 2) (SIR2-related protein 2).
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

NAD-dependent protein deacylase SIR2rp3

Also known as NAD-dependent protein deacylase SIR2rp3 (Regulatory protein SIR2 homolog 5) (SIR2-related protein 3).
NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.

NAD-dependent protein deacylase SIR4

Also known as NAD-dependent protein deacylase SIR4 (Regulatory protein SIR2 homolog 4).
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

NAD-dependent protein deacylase Sirt4

Also known as NAD-dependent protein deacylase Sirt4 (Regulatory protein SIR2 homolog 4).
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.

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