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Pseudopodium-enriched atypical kinase

Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN (By similarity).

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Pseudopodium-enriched atypical kinase 1

Also known as Pseudopodium-enriched atypical kinase 1 (Sugen kinase 269) (Tyrosine-protein kinase SgK269).
PEAK1: a cytoskeleton-associated non-receptor tyrosine kinase that localizes to focal adhesions and actin filaments. Operates downstream of integrin and epidermal growth factor receptors, regulating the P130Cas-Crk-PXN and MAPK signaling. In the late stages of EGF signaling, SGK269 mediates Shc1 protein interactions involved in and cell spreading, migration, and morphogenesis. Amplified in a large fraction of colon cancer. Influences anchorage-independent growth and tumor progression in mice.

Protein type: EC 2.7.10.2; Kinase, protein; NKF3 family; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)

Cellular Component: actin cytoskeleton; cytoplasm; focal adhesion; nucleoplasm; plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein kinase activity

Biological Process: cell migration; protein amino acid autophosphorylation

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