Sodium/hydrogen exchanger
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
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Sodium/hydrogen exchanger 1
NHE1: sodium/hydrogen exchanger 1. Belongs to the Na(+)/H(+) exchanger family. Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 1p36.1-p35
Cellular Component: cytoplasm; endoplasmic reticulum; focal adhesion; integral to membrane; integral to plasma membrane; lamellipodium; lipid raft; nucleoplasm; plasma membrane
Molecular Function: calcium-dependent protein binding; phosphatidylinositol-4,5-bisphosphate binding; potassium:hydrogen antiporter activity; protein binding; protein binding, bridging; protein complex scaffold; protein phosphatase 2B binding; sodium:hydrogen antiporter activity; solute:hydrogen antiporter activity
Biological Process: cell migration; cellular sodium ion homeostasis; hyaluronan catabolic process; ion transport; maintenance of cell polarity; positive regulation of NFAT protein import into nucleus; positive regulation of transcription from RNA polymerase II promoter; protein oligomerization; regulation of focal adhesion formation; regulation of intracellular pH; regulation of pH; regulation of stress fiber formation; response to acidity
Disease: Lichtenstein-knorr Syndrome
Sodium/hydrogen exchanger 10
NHE10: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC). Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Cellular Component: plasma membrane
Molecular Function: potassium:hydrogen antiporter activity; sodium:hydrogen antiporter activity
Biological Process: regulation of intracellular pH; sperm motility
Sodium/hydrogen exchanger 11
NHE11: Involved in pH regulation. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1q25.1
Cellular Component: plasma membrane
Molecular Function: potassium:hydrogen antiporter activity; sodium:hydrogen antiporter activity
Biological Process: regulation of intracellular pH
Sodium/hydrogen exchanger 2
NHE2: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Cellular Component: apical plasma membrane
Molecular Function: sodium:hydrogen antiporter activity
Biological Process: protein localization; regulation of pH; sodium ion transport
Sodium/hydrogen exchanger 3
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Cellular Component: apical plasma membrane; brush border; brush border membrane; plasma membrane; vesicle
Molecular Function: PDZ domain binding; potassium:hydrogen antiporter activity; sodium:hydrogen antiporter activity
Biological Process: receptor-mediated endocytosis; regulation of intracellular pH; regulation of pH; regulation of sodium ion transport; sodium ion transport
Sodium/hydrogen exchanger 4
member of Sodium proton exchanger family
Sodium/hydrogen exchanger 5
Encodes an endosomal Na(+)/H(+) antiporter: AT1G54370 (NHX5), AT1G79610 (NHX6). Double knockout nhx5 nhx6 showed reduced growth, with smaller and fewer cells and increased sensitivity to salinity.
Sodium/hydrogen exchanger 6
Encodes an endosomal Na(+)/H(+) antiporter: AT1G54370 (NHX5), AT1G79610 (NHX6). Double knockout nhx5 nhx6 showed reduced growth, with smaller and fewer cells and increased sensitivity to salinity.
Sodium/hydrogen exchanger 7
Encodes a plasma membrane-localized Na+/H+ antiporter SOS1. Functions in the extrusion of toxic Na+ from cells and is essential for plant salt tolerance. Has 12 predicted transmembrane domains in the N-terminal region and a long cytoplasmic tail of approx. 700 aa at the C-terminal side. SOS1 interacts through its predicted cytoplasmic tail with RCD1, a regulator of oxidative-stress responses, suggesting that SOS1 might function in oxidative-stress tolerance.
Sodium/hydrogen exchanger 8
member of putative Na+/H+ antiporter (AtNHX) family. Functions as a plasma membrane Li+/H+ antiporter. Involved in Li+ efflux and detoxification.
Sodium/hydrogen exchanger 9
NHE9: May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. A chromosomal aberration involving SLC9A9 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9. Defects in SLC9A9 are a cause of susceptibility to autism type 16 (AUTS16). Autism is a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. AUTS16 can be associated with epilepsy. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 3q24
Cellular Component: late endosome membrane; plasma membrane; recycling endosome
Molecular Function: potassium:hydrogen antiporter activity; protein binding; sodium:hydrogen antiporter activity
Biological Process: ion transport; regulation of intracellular pH
Disease: Autism, Susceptibility To, 16
Sodium/hydrogen exchanger 9B1
NHEDC1: is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
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