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Sodium/hydrogen exchanger

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

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Sodium/hydrogen exchanger 1

Also known as Sodium/hydrogen exchanger 1 (APNH) (Na(+)/H(+) antiporter, amiloride-sensitive) (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1).
NHE1: sodium/hydrogen exchanger 1. Belongs to the Na(+)/H(+) exchanger family. Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 1p36.1-p35

Cellular Component: cytoplasm; endoplasmic reticulum; focal adhesion; integral to membrane; integral to plasma membrane; lamellipodium; lipid raft; nucleoplasm; plasma membrane

Molecular Function: calcium-dependent protein binding; phosphatidylinositol-4,5-bisphosphate binding; potassium:hydrogen antiporter activity; protein binding; protein binding, bridging; protein complex scaffold; protein phosphatase 2B binding; sodium:hydrogen antiporter activity; solute:hydrogen antiporter activity

Biological Process: cell migration; cellular sodium ion homeostasis; hyaluronan catabolic process; ion transport; maintenance of cell polarity; positive regulation of NFAT protein import into nucleus; positive regulation of transcription from RNA polymerase II promoter; protein oligomerization; regulation of focal adhesion formation; regulation of intracellular pH; regulation of pH; regulation of stress fiber formation; response to acidity

Disease: Lichtenstein-knorr Syndrome

Sodium/hydrogen exchanger 10

Also known as Sodium/hydrogen exchanger 10 (Na(+)/H(+) exchanger 10) (NHE-10) (Solute carrier family 10 member 10) (Solute carrier family 9 member C1) (Sperm-specific Na(+)/H(+) exchanger) (sNHE).
NHE10: Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC). Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel

Cellular Component: plasma membrane

Molecular Function: potassium:hydrogen antiporter activity; sodium:hydrogen antiporter activity

Biological Process: regulation of intracellular pH; sperm motility

Sodium/hydrogen exchanger 11

Also known as Sodium/hydrogen exchanger 11 (Na(+)/H(+) exchanger 11) (NHE-11) (Solute carrier family 9 member 11) (Solute carrier family 9 member C2).
NHE11: Involved in pH regulation. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: plasma membrane

Molecular Function: potassium:hydrogen antiporter activity; sodium:hydrogen antiporter activity

Biological Process: regulation of intracellular pH

Sodium/hydrogen exchanger 2

Also known as Sodium/hydrogen exchanger 2 (H7) (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2).
NHE2: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Seems to play an important role in colonic sodium absorption. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Cellular Component: apical plasma membrane

Molecular Function: sodium:hydrogen antiporter activity

Biological Process: protein localization; regulation of pH; sodium ion transport

Sodium/hydrogen exchanger 3

NHE3: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Binds SLC9A3R1 and SLC9A3R2. Interacts with SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Cellular Component: apical plasma membrane; brush border; brush border membrane; plasma membrane; vesicle

Molecular Function: PDZ domain binding; potassium:hydrogen antiporter activity; sodium:hydrogen antiporter activity

Biological Process: receptor-mediated endocytosis; regulation of intracellular pH; regulation of pH; regulation of sodium ion transport; sodium ion transport

Sodium/hydrogen exchanger 5

Also known as Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5).
Encodes an endosomal Na(+)/H(+) antiporter: AT1G54370 (NHX5), AT1G79610 (NHX6). Double knockout nhx5 nhx6 showed reduced growth, with smaller and fewer cells and increased sensitivity to salinity.

Sodium/hydrogen exchanger 6

Also known as Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6).
Encodes an endosomal Na(+)/H(+) antiporter: AT1G54370 (NHX5), AT1G79610 (NHX6). Double knockout nhx5 nhx6 showed reduced growth, with smaller and fewer cells and increased sensitivity to salinity.

Sodium/hydrogen exchanger 7

Also known as Sodium/hydrogen exchanger 7 (Na(+)/H(+) exchanger 7) (NHE-7) (Protein SALT OVERLY SENSITIVE 1).
Encodes a plasma membrane-localized Na+/H+ antiporter SOS1. Functions in the extrusion of toxic Na+ from cells and is essential for plant salt tolerance. Has 12 predicted transmembrane domains in the N-terminal region and a long cytoplasmic tail of approx. 700 aa at the C-terminal side. SOS1 interacts through its predicted cytoplasmic tail with RCD1, a regulator of oxidative-stress responses, suggesting that SOS1 might function in oxidative-stress tolerance.

Sodium/hydrogen exchanger 8

Also known as Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Protein SALT OVERLY SENSITIVE 1B).
member of putative Na+/H+ antiporter (AtNHX) family. Functions as a plasma membrane Li+/H+ antiporter. Involved in Li+ efflux and detoxification.

Sodium/hydrogen exchanger 9

Also known as Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9).
NHE9: May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell. A chromosomal aberration involving SLC9A9 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9. Defects in SLC9A9 are a cause of susceptibility to autism type 16 (AUTS16). Autism is a complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. AUTS16 can be associated with epilepsy. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: late endosome membrane; plasma membrane; recycling endosome

Molecular Function: potassium:hydrogen antiporter activity; protein binding; sodium:hydrogen antiporter activity

Biological Process: ion transport; regulation of intracellular pH

Disease: Autism, Susceptibility To, 16

Sodium/hydrogen exchanger 9B1

Also known as Sodium/hydrogen exchanger 9B1 (Na(+)/H(+) exchanger-like domain-containing protein 1) (NHE domain-containing protein 1) (Sodium/hydrogen exchanger-like domain-containing protein 1) (Solute carrier family 9 subfamily B member 1).
NHEDC1: is a sodium/hydrogen exchanger and transmembrane protein. Highly conserved orthologs of this gene have been found in other mammalian species. The expression of this gene may be limited to testis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel

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