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Trinucleotide repeat-containing gene 6A protein

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (By similarity).

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Trinucleotide repeat-containing gene 6A protein

TNRC6A: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. Belongs to the GW182 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Translation

Cellular Component: Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm; perinuclear region of cytoplasm

Molecular Function: protein complex scaffold

Biological Process: cellular response to starvation; maintenance of cellular protein localization; miRNA-mediated gene silencing; miRNA-mediated gene silencing, negative regulation of translation

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