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PSMC3 recombinant protein :: 26S protease regulatory subunit 6A (PSMC3) Recombinant Protein

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Catalog # MBS952560
Unit / Price
Scan QR to view Datasheet
  0.05 mg (E-Coli)  /  $855 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $930 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,145 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,160 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,260 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,265 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,400 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,430 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,680 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $1,915 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,180 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,265 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,270 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,370 +4 FREE 8GB USB
PSMC3 recombinant protein
Product Name

26S protease regulatory subunit 6A (PSMC3), Recombinant Protein

Full Product Name

Recombinant Human 26S protease regulatory subunit 6A (PSMC3)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-439aa, Full length protein
Sequence
MNLLPNIESP VTRQEKMATV WDEAEQDGIG EEVLKMSTEE IIQRTRLLDS EIKIMKSEVL RVTHELQAMK DKIKENSEKI KVNKTLPYLV SNVIELLDVD PNDQEEDGAN IDLDSQRKGK CAVIKTSTRQ TYFLPVIGLV DAEKLKPGDL VGVNKDSYLI LETLPTEYDS RVKAMEVDER PTEQYSDIGG LDKQIQELVE AIVLPMNHKE KFENLGIQPP KGVLMYGPPG TGKTLLARAC AAQTKATFLK LAGPQLVQMF IGDGAKLVRD AFALAKEKAP SIIFIDELDA IGTKRFDSEK AGDREVQRTM LELLNQLDGF QPNTQVKVIA ATNRVDILDP ALLRSGRLDR KIEFPMPNEE ARARIMQIHS RKMNVSPDVN YEELARCTDD FNGAQCKAVC VEAGMIALRR GATELTHEDY MEGILEVQAK KKANLQYYA
OMIM
186852
3D Structure
ModBase 3D Structure for P17980
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PSMC3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PSMC3 recombinant protein
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP
ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
NCBI/Uniprot data below describe general gene information for PSMC3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,204 Da
NCBI Official Full Name
26S proteasome regulatory subunit 6A
NCBI Official Synonym Full Names
proteasome 26S subunit, ATPase 3
NCBI Official Symbol
PSMC3  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
26S proteasome regulatory subunit 6A; 26S protease regulatory subunit 6A
UniProt Protein Name
26S proteasome regulatory subunit 6A
UniProt Synonym Protein Names
26S proteasome AAA-ATPase subunit RPT5; Proteasome 26S subunit ATPase 3; Proteasome subunit P50; Tat-binding protein 1; TBP-1
Protein Family
UniProt Gene Name
PSMC3  [Similar Products]
UniProt Synonym Gene Names
TBP1; TBP-1  [Similar Products]
NCBI Summary for PSMC3
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
UniProt Comments for PSMC3
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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