NP_000950.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
prostaglandin F2-alpha receptor isoform a
NCBI Official Synonym Full Names
prostaglandin F receptor (FP)
NCBI Official Synonym Symbols
NCBI Protein Information
prostaglandin F2-alpha receptor; PGF receptor; PGF2 alpha receptor; PGF2-alpha receptor; prostanoid FP receptor; prostaglandin F2 alpha receptor; prostaglandin receptor (2-alpha)
UniProt Protein Name
Prostaglandin F2-alpha receptor
UniProt Synonym Protein Names
Prostanoid FP receptor
UniProt Synonym Gene Names
UniProt Entry Name
PF2R_HUMAN
NCBI Summary for PTGFR
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PTGFR
PTGFR: Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1p31.1
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; extracellular region
Molecular Function: prostaglandin F receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; response to lipopolysaccharide; parturition; negative regulation of apoptosis
Research Articles on PTGFR
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Products associated with PTGFR recombinant protein
Pathways associated with PTGFR recombinant protein
Diseases associated with PTGFR recombinant protein
Organs/Tissues associated with PTGFR recombinant protein
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