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PTGS1 recombinant protein :: Prostaglandin G/H synthase 1 (PTGS1) Recombinant Protein

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Catalog # MBS718735
Unit / Price
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  0.05 mg (E-Coli)  /  $995 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $1,040 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,280 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,345 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,420 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,485 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,520 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,605 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,850 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,250 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,390 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,450 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,535 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,680 +4 FREE 8GB USB
SDS-PAGE
Product Name

Prostaglandin G/H synthase 1 (PTGS1), Recombinant Protein

Popular Item
Full Product Name

Recombinant Human Prostaglandin G/H synthase 1 (PTGS1)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
24-599aa, Full Length of Mature Protein
Sequence
ADPGAPTPVN PCCYYPCQHQ GICVRFGLDR YQCDCTRTGY SGPNCTIPGL WTWLRNSLRP SPSFTHFLLT HGRWFWEFVN ATFIREMLMR LVLTVRSNLI PSPPTYNSAH DYISWESFSN VSYYTRILPS VPKDCPTPMG TKGKKQLPDA QLLARRFLLR RKFIPDPQGT NLMFAFFAQH FTHQFFKTSG KMGPGFTKAL GHGVDLGHIY GDNLERQYQL RLFKDGKLKY QVLDGEMYPP SVEEAPVLMH YPRGIPPQSQ MAVGQEVFGL LPGLMLYATL WLREHNRVCD LLKAEHPTWG DEQLFQTTRL ILIGETIKIV IEEYVQQLSG YFLQLKFDPE LLFGVQFQYR NRIAMEFNHL YHWHPLMPDS FKVGSQEYSY EQFLFNTSML VDYGVEALVD AFSRQIAGRI GGGRNMDHHI LHVAVDVIRE SREMRLQPFN EYRKRFGMKP YTSFQELVGE KEMAAELEEL YGDIDALEFY PGLLLEKCHP NSIFGESMIE IGAPFSLKGL LGNPICSPEY WKPSTFGGEV GFNIVKTATL KKLVCLNTKT CPYVSFRVPD ASQDDGPAVE RPSTEL
OMIM
176805
3D Structure
ModBase 3D Structure for P23219
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of PTGS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PTGS1 recombinant protein
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

PTGS1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for PTGS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,010 Da
NCBI Official Full Name
prostaglandin G/H synthase 1 isoform 1
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 1
NCBI Official Symbol
PTGS1  [Similar Products]
NCBI Official Synonym Symbols
COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1
  [Similar Products]
NCBI Protein Information
prostaglandin G/H synthase 1
UniProt Protein Name
Prostaglandin G/H synthase 1
UniProt Synonym Protein Names
Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
UniProt Gene Name
PTGS1  [Similar Products]
UniProt Synonym Gene Names
COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1  [Similar Products]
NCBI Summary for PTGS1
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Comments for PTGS1
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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