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PTH protein :: Parathyroid Hormone1-84 Protein

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Catalog # MBS546093
Unit / Price
  0.02 mg  /  $165 +1 FREE 8GB USB
  0.1 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $810 +1 FREE 8GB USB
PTH protein
Product Name

Parathyroid Hormone1-84 (PTH), Protein

Popular Item
Also Known As

Recombinant Human Parathyroid Hormone 1-84 (rHu PTH1-84)

Product Synonym Names
Parathyroid Hormone1-84; human PTH (1-84); Human Parathyroid Hormone
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
115
Chromosome Location
Chromosome: 11; NC_000011.9 (13513601..13517567, complement). Location: 11p15.3-p15.1
OMIM
146200
3D Structure
ModBase 3D Structure for P01270
Purity/Purification
>97% by SDS-PAGE and HPLC analyses.
Form/Format
Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in 20mM PB, pH 7.0, containing 4% mannitol.
Source
E.coli
Molecular Weight
Approximately 10kDa, a single non-glycosylated polypeptide chain containing 84 amino acids
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Biological Activity
Fully biologically active when compared to standard. The activity calculated by UMR106 cell/cAMP method corresponding to a specific activity of 0.9 x 104 Units/mg.
Endotoxin Level
Less than 1EU/mg of rHuPTH1-84 as determined by LAL method.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <= -20°C. Further dilutions should be made in appropriate buffered solutions.
Preparation and Storage
This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles
Other Notes
Small volumes of PTH protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PTH protein
Polypeptide hormones secreted by the parathyroid glands, which promote release of calcium from bone to extracellular fluid by activating osteoblasts and inhibiting osteoclasts, indirectly promote increased intestinal absorption of calcium, and promote renal tubular reabsorption of calcium and increased renal excretion of phosphates. It is a major regulator of bone metabolism. Secretion of parathyroid hormone increases when the level of calcium in the extracellular fluid is low. Its action is opposed by calcitonin.
NCBI/Uniprot data below describe general gene information for PTH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Parathyroid hormone
NCBI Official Synonym Full Names
parathyroid hormone
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
parathyroid hormone; parathyrin; prepro-PTH; parathormone; parathyroid hormone 1; preproparathyroid hormone
UniProt Protein Name
Parathyroid hormone
UniProt Synonym Protein Names
Parathormone; Parathyrin
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
PTHY_HUMAN
NCBI Summary for PTH
The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]
UniProt Comments for PTH
PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family.

Protein type: Secreted; Apoptosis; Hormone; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.3-p15.1

Cellular Component: extracellular space; extracellular region

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; type 1 parathyroid hormone receptor binding; parathyroid hormone receptor binding; peptide hormone receptor binding; hormone activity

Biological Process: transcription from RNA polymerase II promoter; response to drug; positive regulation of signal transduction; induction of apoptosis by hormones; positive regulation of glycogen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; Rho protein signal transduction; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; positive regulation of glucose import; response to ethanol; cAMP metabolic process; response to vitamin D; response to cadmium ion; cell-cell signaling; regulation of gene expression; response to lead ion; positive regulation of cAMP biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; skeletal development; bone resorption

Disease: Hypoparathyroidism, Familial Isolated
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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