PTPN11 elisa kit :: Porcine Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of PTPN11 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS7243588 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PTPN11. The ELISA analytical biochemical technique of the MBS7243588 kit is based on PTPN11 antibody-PTPN11 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PTPN11 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PTPN11. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

68,033 Da

protein tyrosine phosphatase, non-receptor type 11

tyrosine-protein phosphatase non-receptor type 11; null; SHP-2; PTP-1D; encodes catalytic domain; protein-tyrosine phosphatase 1D; protein-tyrosine phosphatase SYP; protein tyrosine phosphatase SH-PTP2; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11

Tyrosine-protein phosphatase non-receptor type 11

PTP-1D; SHP-2; Shp2  [Similar Products]

PTN11_RAT

catalyzes the tyrosine dephosphorylation of para-nitrophenylphosphate, nicotinic acetylcholine receptor, myelin basic protein, and other proteins [RGD, Feb 2006]

SHP-2: a SH2-containing a ubiquitously expressed tyrosine-specific protein phosphatase. It participates in signaling events downstream of receptors for growth factors, cytokines, hormones, antigens and extracellular matrices in the control of cell growth, differentiation, migration, and death. Activation of SHP-2 and its association with Gab1 is critical for sustained Erk activation downstream of several growth factor receptors and cytokines.

Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis

Cellular Component: protein complex; mitochondrion; cytoplasm; nucleus; cytosol

Molecular Function: protein domain specific binding; protein binding; phospholipase binding; SH3/SH2 adaptor activity; peptide hormone receptor binding; insulin receptor substrate binding; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; D1 dopamine receptor binding; phosphoprotein phosphatase activity; insulin receptor binding

Biological Process: hormone-mediated signaling; nerve growth factor receptor signaling pathway; activation of MAPK activity; negative regulation of hormone secretion; heart development; platelet-derived growth factor receptor signaling pathway; protein amino acid dephosphorylation; positive regulation of mitotic cell cycle; glucose homeostasis; reproductive process in a multicellular organism; regulation of protein export from nucleus; negative regulation of insulin secretion; regulation of cell adhesion mediated by integrin; microvillus organization and biogenesis; ephrin receptor signaling pathway; abortive mitotic cell cycle; inner ear development; negative regulation of cell adhesion mediated by integrin; epidermal growth factor receptor signaling pathway; integrin-mediated signaling pathway; negative regulation of growth hormone secretion; positive regulation of signal transduction; multicellular organism growth; positive regulation of hormone secretion; regulation of multicellular organism growth; negative regulation of cortisol secretion; organ growth; genitalia development; triacylglycerol metabolic process; axonogenesis; dephosphorylation; homeostasis of number of cells within a tissue; DNA damage checkpoint; hormone metabolic process; brain development; platelet formation; lipid metabolic process

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