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PTPRN recombinant protein :: Protein Tyrosine Phosphatase IA2 Recombinant Protein

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Catalog # MBS636676
Unit / Price
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  0.02 mg  /  $675 +1 FREE 8GB USB
Test Data
Product Name

Protein Tyrosine Phosphatase IA2 (PTPRN), Recombinant Protein

Popular Item
Full Product Name

Protein Tyrosine Phosphatase IA2 (693-979), Recombinant, Human (PTP-IA2, ICA-512)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (220154345..220174295, complement). Location: 2q35-q36.1
3D Structure
ModBase 3D Structure for Q16849
Recombinant, Human from E Coli
Species Reactivity
Supplied as a liquid in 25 Mm Tris-HCl, pH 8.0, 75 mM sodium chloride, 0.05% Tween-20, 2mM EDTA, 1mM DTT, 10mM glutathione, 50% glycerol.
2.16 mg/ml (lot specific)
Preparation and Storage
Store at -70 degree C. Stable for 6 months after receipt. For maximum recovery of product, centriuge the original vial after thawing and prior to removing the cap.
Shipping: Ships with Dry Ice.
Other Notes
Small volumes of PTPRN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PTPRN recombinant protein
Recombinant protein corresponding to aa693-979 from human Protein Tyrosine Phosphate, with N-terminal GST tag, expressed in E.coli
Application Notes for PTPRN recombinant protein
Suitable for the use as an immunogen, in binding assays or as an antigen in autoimmune assays. Other applications not tested.
Recommended Dilution: Optimal dilution to be determined by researcher.

4-20% SDS-PAGE Coomassie Staining
PTPRN recombinant protein Test Data image
NCBI/Uniprot data below describe general gene information for PTPRN. It may not necessarily be applicable to this product.
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
PTPRN protein, partial
NCBI Official Synonym Full Names
protein tyrosine phosphatase, receptor type, N
NCBI Official Symbol
PTPRN  [Similar Products]
NCBI Official Synonym Symbols
IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP
  [Similar Products]
NCBI Protein Information
receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N
UniProt Protein Name
Receptor-type tyrosine-protein phosphatase-like N
UniProt Synonym Protein Names
Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2
UniProt Gene Name
PTPRN  [Similar Products]
UniProt Synonym Gene Names
ICA3; ICA512; R-PTP-N; ICA 512  [Similar Products]
UniProt Entry Name
NCBI Summary for PTPRN
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
UniProt Comments for PTPRN
PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q35-q36.1

Cellular Component: integral to membrane

Molecular Function: GTPase binding; protein binding; spectrin binding; protein tyrosine phosphatase activity

Biological Process: response to reactive oxygen species; response to cAMP; response to estrogen stimulus; insulin secretion; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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