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Pttg1 recombinant protein :: Securin (Pttg1) Recombinant Protein

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Catalog # MBS717749
Unit / Price
  0.05 mg (E-Coli)  /  $595 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $800 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $880 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $895 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,005 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,130 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,135 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,135 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,240 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,635 +2 FREE 8GB USB
  1 mg (Yeast)  /  $1,725 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,730 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,180 +2 FREE 8GB USB
Pttg1 recombinant protein
Product Name

Securin (Pttg1), Recombinant Protein

Also Known As

Recombinant Rat Securin (Pttg1)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
2-199aa, Full Length of Mature Protein
Sequence Length
199
Sequence
ATLIFVDKDN EEPGSRLASK DGLKLGSGVK ALDGKLQVST PRVGKVFGAP GLPKASRKAL GTVNRVTEKP VKSSKPLQSK QPTLSVKKIT EKSTKTQGSA PAPDDAYPEI EKFFPFDPLD FESFDLPEEH QISLLPLNGV PLMILNEERG LEKLLHLDPP SPLQKPFLPW ESDPLPSPPS ALSALDVELP PVCYDADI
3D Structure
ModBase 3D Structure for P97613
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rat
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Pttg1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Pttg1 recombinant protein
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
NCBI/Uniprot data below describe general gene information for Pttg1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
21,571 Da
NCBI Official Full Name
securin
NCBI Official Synonym Full Names
pituitary tumor-transforming 1
NCBI Official Symbol
Pttg1  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
securin
UniProt Protein Name
Securin
UniProt Synonym Protein Names
Pituitary tumor-transforming gene 1 protein
UniProt Gene Name
Pttg1  [Similar Products]
UniProt Synonym Gene Names
UniProt Comments for Pttg1
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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