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CA2 purified protein :: CARBONIC ANHYDRASE Purified Protein

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Catalog # MBS230374
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CA2 purified protein
Product Name

CARBONIC ANHYDRASE (CA2), Purified Protein

Popular Item
Full Product Name

NATIVE BOVINE CARBONIC ANHYDRASE

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P00921
Form/Format
Purified
Purified protein from bovine erythrocytes - liquid
Concentration
Total protein concentration 200mg/ml. (lot specific)
Preparation
0.75g protein/g (1 unit as described above is equivalent to approximately 2000 Wilbur Anderson units [J. Biol. Chem. (1948) 176:147]
Activity
700 U/g 1 unit hydrolyses 1 umole of p-nitrophenyl acetate per minute at pH 7.6 / 25 degree C
Target Species
Bovine
Preparation and Storage
Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
Other Notes
Small volumes of CA2 purified protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CA2 purified protein
Native Bovine Carbonic Anhydrase is a zinc-containing enzyme that acts as a catalyst in the conversion of carbon dioxide to bicarbonate.
Applications Tested/Suitable for CA2 purified protein
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for CA2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Protein Molecular Weight: 30 kDa[Similar Products]
NCBI Official Full Name
carbonic anhydrase 2
NCBI Official Synonym Full Names
carbonic anhydrase II
NCBI Official Symbol
NCBI Protein Information
carbonic anhydrase 2; CA-II; carbonate dehydratase II
UniProt Protein Name
Carbonic anhydrase 2
UniProt Synonym Protein Names
Carbonate dehydratase II; Carbonic anhydrase II; CA-II
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CA-II  [Similar Products]
UniProt Entry Name
CAH2_BOVIN
UniProt Comments for CA2
CA2: Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity. Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala- His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO(3)). Esterase activity weakly reduced by cyanamide. N- hydroxyurea interfers with zinc binding and inhibit activity. Belongs to the alpha-carbonic anhydrase family.

Protein type: Lyase; EC 4.2.1.1; Energy Metabolism - nitrogen

Cellular Component: cytoplasm; plasma membrane

Molecular Function: carbonate dehydratase activity; zinc ion binding

Biological Process: regulation of intracellular pH; one-carbon compound metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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