NP_068688.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,093 Da
NCBI Official Full Name
queuine tRNA-ribosyltransferase catalytic subunit 1
NCBI Official Synonym Full Names
queuine tRNA-ribosyltransferase catalytic subunit 1
NCBI Protein Information
queuine tRNA-ribosyltransferase catalytic subunit 1; queuine tRNA-ribosyltransferase
UniProt Protein Name
Queuine tRNA-ribosyltransferase catalytic subunit 1
UniProt Synonym Protein Names
Guanine insertion enzyme
UniProt Comments for Qtrt1
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GUN anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:19414587). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product ().
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Products associated with Qtrt1 recombinant protein
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