NP_001258967.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,774 Da
NCBI Official Full Name
ras-related protein Rab-13 isoform 2
NCBI Official Synonym Full Names
RAB13, member RAS oncogene family
NCBI Official Synonym Symbols
NCBI Protein Information
ras-related protein Rab-13
UniProt Protein Name
Ras-related protein Rab-13
UniProt Synonym Protein Names
Cell growth-inhibiting gene 4 protein
UniProt Entry Name
RAB13_HUMAN
NCBI Summary for RAB13
This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]
UniProt Comments for RAB13
RAB13: Could participate in polarized transport, in the assembly and/or the activity of tight junctions. Belongs to the small GTPase superfamily. Rab family.
Protein type: G protein, monomeric, Rab; G protein, monomeric; G protein
Chromosomal Location of Human Ortholog: 1q21.2
Cellular Component: Golgi apparatus; recycling endosome; neuron projection; cytoplasmic vesicle membrane; tight junction; lamellipodium; endocytic vesicle; recycling endosome membrane; cytoplasm; plasma membrane; trans-Golgi network; cytoplasmic vesicle; lateral plasma membrane
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding
Biological Process: intracellular protein transport; cellular response to insulin stimulus; metabolic process; cortical actin cytoskeleton organization and biogenesis; endosome transport; endocytic recycling; Rab protein signal transduction; neurite development
Research Articles on RAB13
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Products associated with RAB13 sirna
Pathways associated with RAB13 sirna
Diseases associated with RAB13 sirna
Organs/Tissues associated with RAB13 sirna
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