CAA81393.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
108,378 Da
NCBI Official Full Name
FLT3 receptor tyrosine kinase
NCBI Official Synonym Full Names
fms related tyrosine kinase 3
NCBI Protein Information
receptor-type tyrosine-protein kinase FLT3
UniProt Protein Name
Receptor-type tyrosine-protein kinase FLT3
UniProt Synonym Protein Names
FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen: CD135
UniProt Synonym Gene Names
NCBI Summary for FLT3
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
UniProt Comments for FLT3
FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 13q12.2
Cellular Component: endoplasmic reticulum; integral to plasma membrane; plasma membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; protein self-association; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity
Biological Process: B cell differentiation; cytokine and chemokine mediated signaling pathway; hemopoiesis; leukocyte homeostasis; lymphocyte proliferation; myeloid progenitor cell differentiation; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of STAT protein; pro-B cell differentiation; protein amino acid autophosphorylation; regulation of apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Leukemia, Acute Lymphoblastic
Research Articles on FLT3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with FLT3 elisa kit
Pathways associated with FLT3 elisa kit
Diseases associated with FLT3 elisa kit
Disease Name |
Pubmed Publications |
Neoplasms Antibodies |
>1851 publications with FLT3 and Neoplasms |
Leukemia, Myeloid, Acute Antibodies |
>1556 publications with FLT3 and Leukemia, Myeloid, Acute |
Bone Marrow Diseases Antibodies |
>274 publications with FLT3 and Bone Marrow Diseases |
Cell Transformation, Neoplastic Antibodies |
>141 publications with FLT3 and Cell Transformation, Neoplastic |
Leukemia, Promyelocytic, Acute Antibodies |
>129 publications with FLT3 and Leukemia, Promyelocytic, Acute |
Necrosis Antibodies |
>115 publications with FLT3 and Necrosis |
Neoplasms, Experimental Antibodies |
>93 publications with FLT3 and Neoplasms, Experimental |
Carcinoma Antibodies |
>87 publications with FLT3 and Carcinoma |
Inflammation Antibodies |
>72 publications with FLT3 and Inflammation |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies |
>70 publications with FLT3 and Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
Organs/Tissues associated with FLT3 elisa kit
|