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RAD51C peptide

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Catalog # MBS426727
Unit / Price
  0.1 mg  /  $190 +1 FREE 8GB USB
RAD51C peptide
Product Name

RAD51C, Peptide

Also Known As

RAD51C Immunizing Peptide

Product Synonym Names
RAD51C; RAD51 homolog C (S. cerevisiae); RAD51L2; yeast RAD51 homolog 3; DNA repair protein RAD51 homolog 3; MGC104277; RAD51 homolog C; RAD51 homolog C, isoform 1
Product Gene Name
Antibody/Peptide Pairs
RAD51C peptide (MBS426727) is used for blocking the activity of RAD51C antibody (MBS420543)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
135
Sequence
RGKTFRFEMQ RDL-C
OMIM
602774
Species Reactivity
Human
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of RAD51C peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for RAD51C. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_478123.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,883 Da
NCBI Official Full Name
DNA repair protein RAD51 homolog 3 isoform 2
NCBI Official Synonym Full Names
RAD51 paralog C
NCBI Official Symbol
RAD51C  [Similar Products]
NCBI Official Synonym Symbols
FANCO; R51H3; BROVCA3; RAD51L2
  [Similar Products]
NCBI Protein Information
DNA repair protein RAD51 homolog 3
UniProt Protein Name
DNA repair protein RAD51 homolog 3
UniProt Synonym Protein Names
RAD51 homolog C; RAD51-like protein 2
Protein Family
UniProt Gene Name
RAD51C  [Similar Products]
UniProt Synonym Gene Names
RAD51L2; R51H3  [Similar Products]
UniProt Entry Name
RA51C_HUMAN
NCBI Summary for RAD51C
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Comments for RAD51C
RAD51C: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis. Defects in RAD51C are the cause of Fanconi anemia complementation group O (FANCO). It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Defects in RAD51C are the cause of familial breast- ovarian cancer type 3 (BROVCA3). It is a condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. Belongs to the RecA family. RAD51 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: condensed nuclear chromosome; cytoplasm; mitochondrion; nucleoplasm; nucleus; perinuclear region of cytoplasm; replication fork

Molecular Function: ATP binding; crossover junction endodeoxyribonuclease activity; DNA binding; DNA-dependent ATPase activity; double-stranded DNA binding; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding

Biological Process: blood coagulation; DNA recombinase assembly; DNA recombination; DNA repair; DNA synthesis during DNA repair; double-strand break repair via homologous recombination; female meiosis sister chromatid cohesion; male meiosis I; meiotic recombination; mitotic recombination; response to ionizing radiation; sister chromatid cohesion; spermatogenesis; strand displacement; strand invasion; telomere maintenance via recombination

Disease: Breast-ovarian Cancer, Familial, Susceptibility To, 3; Fanconi Anemia, Complementation Group O; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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