NP_002869
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37.4 kDa (351aa) confirmed by MALDI-TOF
NCBI Official Full Name
DNA repair protein RAD51 homolog 4 isoform 1
NCBI Official Synonym Full Names
RAD51 paralog D
NCBI Protein Information
DNA repair protein RAD51 homolog 4
UniProt Protein Name
DNA repair protein RAD51 homolog 4
UniProt Synonym Protein Names
R51H3; RAD51 homolog D; RAD51-like protein 3; TRAD
UniProt Synonym Gene Names
NCBI Summary for RAD51D
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]
UniProt Comments for RAD51D
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.
Product References and Citations for RAD51D recombinant protein
Masson J.Y., et al. (2001) Genes Dev. 15:3296-3307; Liu N., et al. (2002) Nucleic Acids Res. 30:1009-1015;
Research Articles on RAD51D
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Products associated with RAD51D recombinant protein
Pathways associated with RAD51D recombinant protein
Diseases associated with RAD51D recombinant protein
Organs/Tissues associated with RAD51D recombinant protein
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