NP_659099
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
99,452 Da
NCBI Official Full Name
rap guanine nucleotide exchange factor 3 isoform a
NCBI Official Synonym Full Names
Rap guanine nucleotide exchange factor (GEF) 3
NCBI Official Synonym Symbols
EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI [Similar Products]
NCBI Protein Information
rap guanine nucleotide exchange factor 3; EPAC 1; 9330170P05Rik; exchange factor directly activated by cAMP 1; exchange protein directly activated by cAMP 1; cAMP-regulated guanine nucleotide exchange factor I; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
UniProt Protein Name
Rap guanine nucleotide exchange factor 3
UniProt Synonym Protein Names
Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; EPAC 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI
UniProt Synonym Gene Names
UniProt Entry Name
RPGF3_HUMAN
UniProt Comments for RAPGEF3
Epac1: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, misc.; GEFs
Chromosomal Location of Human Ortholog: 12q13.1
Cellular Component: membrane; plasma membrane; endomembrane system; cAMP-dependent protein kinase complex
Molecular Function: Rap guanyl-nucleotide exchange factor activity; protein binding; guanyl-nucleotide exchange factor activity; cAMP-dependent protein kinase regulator activity; cAMP binding
Biological Process: positive regulation of syncytium formation by plasma membrane fusion; platelet activation; signal transduction; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein export from nucleus; cell proliferation; cAMP-mediated signaling; positive regulation of angiogenesis; positive regulation of stress fiber formation; energy reserve metabolic process; positive regulation of cAMP catabolic process; angiogenesis; regulation of protein kinase activity; blood coagulation; regulation of insulin secretion; Rap protein signal transduction
Research Articles on RAPGEF3
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Products associated with RAPGEF3 blocking peptide
Pathways associated with RAPGEF3 blocking peptide
Diseases associated with RAPGEF3 blocking peptide
Organs/Tissues associated with RAPGEF3 blocking peptide
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