NP_001276608.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,697 Da
NCBI Official Full Name
aryl hydrocarbon receptor nuclear translocator-like protein 2 isoform 2
NCBI Official Synonym Full Names
aryl hydrocarbon receptor nuclear translocator-like 2
NCBI Official Synonym Symbols
CLIF; MOP9; BMAL2; bHLHe6; 4632430A05Rik [Similar Products]
NCBI Protein Information
aryl hydrocarbon receptor nuclear translocator-like protein 2; brain and muscle ARNT-like 2; brain-muscle-ARNT-like protein 2
UniProt Protein Name
Aryl hydrocarbon receptor nuclear translocator-like protein 2
UniProt Synonym Protein Names
Brain and muscle ARNT-like 2
UniProt Synonym Gene Names
UniProt Entry Name
BMAL2_MOUSE
NCBI Summary for ARNTL2
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (Per, Arnt, Sim) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian Clock protein, the structurally related Mop4, and hypoxia-inducible factors, such as Hif1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]
UniProt Comments for ARNTL2
ARNTL2: ARNTL2-CLOCK heterodimers activate E-box element (5'- CACGTG-5') transcription. Also, in umbilical vein endothelial cells, activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. 8 isoforms of the human protein are produced by alternative splicing.
Cellular Component: transcription factor complex; cytoplasm; nucleolus; nucleus
Molecular Function: protein dimerization activity; signal transducer activity; protein binding; DNA binding; transcription factor activity
Biological Process: circadian rhythm; transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; rhythmic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of circadian rhythm; signal transduction
Research Articles on ARNTL2
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Pathways associated with ARNTL2 elisa kit
Diseases associated with ARNTL2 elisa kit
Organs/Tissues associated with ARNTL2 elisa kit
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