EAW59424.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,612 Da
NCBI Official Full Name
ATPase, H+ transporting, lysosomal accessory protein 2
NCBI Official Synonym Full Names
ATPase, H+ transporting, lysosomal accessory protein 2
NCBI Official Synonym Symbols
PRR; M8-9; MRXE; RENR; XMRE; XPDS; HT028; MRXSH; ELDF10; ATP6IP2; MSTP009; APT6M8-9; ATP6M8-9 [Similar Products]
NCBI Protein Information
renin receptor
UniProt Protein Name
Renin receptor
UniProt Synonym Protein Names
ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ER-localized type I transmembrane adaptor; Embryonic liver differentiation factor 10; N14F; Renin/prorenin receptor; Vacuolar ATP synthase membrane sector-associated protein M8-9; ATP6M8-9; V-ATPase M8.9 subunit
UniProt Synonym Gene Names
UniProt Entry Name
RENR_HUMAN
NCBI Summary for ATP6AP2
This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP6AP2
ATP6AP2: Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS). Defects in ATP6AP2 are a cause of mental retardation X- linked with epilepsy (MRXE). MRXE is a syndromic mental retardation. Patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp11.4
Cellular Component: neuron projection; integral to membrane; plasma membrane; external side of plasma membrane
Molecular Function: protein binding; enzyme binding; receptor activity; aspartic-type endopeptidase activity
Biological Process: positive regulation of transforming growth factor-beta1 production; rostrocaudal neural tube patterning; cellular protein metabolic process; regulation of MAPKKK cascade; angiotensin maturation; proteolysis; positive regulation of Wnt receptor signaling pathway; eye pigmentation
Disease: Mental Retardation, X-linked, Syndromic, Hedera Type; Parkinsonism With Spasticity, X-linked
Research Articles on ATP6AP2
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Pathways associated with ATP6AP2 elisa kit
Diseases associated with ATP6AP2 elisa kit
Organs/Tissues associated with ATP6AP2 elisa kit
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