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RB1CC1 elisa kit :: Human RB1-inducible coiled-coil 1 ELISA Kit

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Catalog # MBS9337415
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RB1CC1 elisa kit
Product Name

RB1-inducible coiled-coil 1 (RB1CC1), ELISA Kit

Full Product Name

Human RB1-inducible coiled-coil protein 1, RB1CC1 ELISA Kit

Product Synonym Names
Human RB1-inducible coiled-coil protein 1 (RB1CC1) ELISA kit; CC1; FIP200; 200 kDa FAK family kinase-interacting protein; Rb1-inducible coiled coil protein 1; RB1-inducible coiled-coil 1
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
OMIM
606837
3D Structure
ModBase 3D Structure for Q8TDY2
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of RB1CC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for RB1CC1purchase
MBS9337415 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the RB1-inducible coiled-coil 1 (RB1CC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RB1CC1. The ELISA analytical biochemical technique of the MBS9337415 kit is based on RB1CC1 antibody-RB1CC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RB1CC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RB1CC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for RB1CC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
183,091 Da
NCBI Official Full Name
RB1-inducible coiled-coil protein 1 isoform 2
NCBI Official Synonym Full Names
RB1-inducible coiled-coil 1
NCBI Official Symbol
RB1CC1  [Similar Products]
NCBI Official Synonym Symbols
CC1; ATG17; FIP200; PPP1R131
  [Similar Products]
NCBI Protein Information
RB1-inducible coiled-coil protein 1; phosphatase 1, regulatory subunit 131; 200 kDa FAK family kinase-interacting protein; FAK family kinase-interacting protein of 200 kDa
UniProt Protein Name
RB1-inducible coiled-coil protein 1
UniProt Synonym Protein Names
FAK family kinase-interacting protein of 200 kDa; FIP200
UniProt Gene Name
RB1CC1  [Similar Products]
UniProt Synonym Gene Names
KIAA0203; RBICC; FIP200  [Similar Products]
UniProt Entry Name
RBCC1_HUMAN
NCBI Summary for RB1CC1
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
UniProt Comments for RB1CC1
RB1CC1: a putative transcription factor that functions as a key regulator of Rb expression. Required for autophagosome formation. Contains a nuclear localization signal, a leucine zipper motif and a coiled-coil structure. Thought to play a biological role in controlling cell growth and progression of various cancers. Probably involved in the tumorigenesis of breast cancer. It is frequently mutated in breast cancer and shows characteristics of a classical tumor suppressor gene. Plays a crucial role in muscular differentiation and required for myogenic differentiation. Part of a complex consisting of ATG13, ULK1 and RB1CC1. This complex associates with ATG101. Under starvation conditions, is localized to phagophores. Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells. Expression was difficult to detect in immature proliferating chondroblasts or myogenic cells in embryos, but became obvious and prominent concomitantly with the maturation of osteocytes, chondrocytes, and skeletal muscle cells. Expression in these musculoskeletal cells increased with RB1 expression, which is linked to the terminal differentiation of many tissues and cells. The introduction of the wild-type protein decreased the formation of macroscopic colonies in a cell growth assay.

Protein type: Tumor suppressor; Autophagy; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 8q11

Cellular Component: nuclear membrane; cytoplasm; pre-autophagosomal structure membrane; cytosol

Molecular Function: protein binding; protein kinase binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell size; heart development; JNK cascade; regulation of autophagy; positive regulation of protein amino acid phosphorylation; cell cycle; liver development; autophagic vacuole formation

Disease: Breast Cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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