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RBP3 recombinant protein :: Retinol-binding protein 3 Recombinant Protein

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Catalog # MBS962924
Unit / Price
  0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
  0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
  0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
  0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
  0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
SDS-Page
Product Name

Retinol-binding protein 3 (RBP3), Recombinant Protein

Popular Item
Also Known As

Recombinant Bovine Retinol-binding protein 3

Product Synonym Names
Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
933-1231aa; Partial
Sequence Length
1247
Sequence
AKVPTVLQTA GKLVADNYAS PELGVKMAAE LSGLQSRYAR VTSEAALAEL LQADLQVLSG DPHLKTAHIP EDAKDRIPGI VPMQIPSPEV FEDLIKFSFH TNVLEGNVGY LRFDMFGDCE LLTQVSELLV EHVWKKIVHT DALIVDMRFN IGGPTSSISA LCSYFFDEGP PILLDKIYNR PNNSVSELWT LSQLEGERYG SKKSMVILTS TLTAGAAEEF TYIMKRLGRA LVIGEVTSGG CQPPQTYHVD DTDLYLTIPT ARSVGAADGS SWEGVGVVPD VAVPAEAALT RAQEMLQHT
OMIM
180290
3D Structure
ModBase 3D Structure for P10745
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater than 90% as determined by SDS-PAGE. (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of RBP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RBP3 recombinant protein
IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.

RBP3 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for RBP3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59.8kD
NCBI Official Full Name
retinol-binding protein 3
NCBI Official Synonym Full Names
retinol binding protein 3
NCBI Official Symbol
NCBI Official Synonym Symbols
IRBP; RBPI; RP66; D10S64; D10S65; D10S66
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NCBI Protein Information
retinol-binding protein 3
UniProt Protein Name
Retinol-binding protein 3
UniProt Synonym Protein Names
Interphotoreceptor retinoid-binding protein; IRBP; Interstitial retinol-binding protein
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
RET3_HUMAN
NCBI Summary for RBP3
Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]
UniProt Comments for RBP3
RBP3: IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Belongs to the peptidase S41A family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10q11.2

Cellular Component: extracellular region; extracellular space

Molecular Function: retinal binding; retinoid binding; retinol binding; serine-type peptidase activity

Biological Process: lipid metabolic process; phototransduction, visible light; proteolysis; retinoid metabolic process; transport; visual perception

Disease: Retinitis Pigmentosa; Retinitis Pigmentosa 66
Product References and Citations for RBP3 recombinant protein
Human interstitial retinoid-binding protein. Gene structure and primary structure.Liou G.I., Ma D.-P., Yang Y.-W., Geng L., Zhu C., Baehr W.J. Biol. Chem. 264:8200-8206(1989) Characterization and comparative structural features of the gene for human interstitial retinol-binding protein.Fong S.-L., Fong W.B., Morris T.A., Kedzie K.M., Bridges C.D.B.J. Biol. Chem. 265:3648-3653(1990) Cloning of cDNAs encoding human interphotoreceptor retinoid-binding protein (IRBP) and comparison with bovine IRBP sequences.Si J.S., Borst D.E., Redmond T.M., Nickerson J.M.Gene 80:99-108(1989) Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA.Fong S.-L., Bridges C.D.B.J. Biol. Chem. 263:15330-15334(1988) Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.Oshikawa M., Tsutsui C., Ikegami T., Fuchida Y., Matsubara M., Toyama S., Usami R., Ohtoko K., Kato S.Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) The DNA sequence and comparative analysis of human chromosome 10.Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.Nature 429:375-381(2004)

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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