AAH18906
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52.6 kDa (476aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
NCBI Official Full Name
B-cell linker
NCBI Official Synonym Full Names
B cell linker
NCBI Official Synonym Symbols
bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65 [Similar Products]
NCBI Protein Information
B-cell linker protein
UniProt Protein Name
B-cell linker protein
UniProt Synonym Protein Names
B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa; SLP-65
UniProt Synonym Gene Names
NCBI Summary for BLNK
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
UniProt Comments for BLNK
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Product References and Citations for BLNK recombinant protein
Kurosaki T, et al. (1997) Curr. Opin. Immunol., 9:309-318.; Fu C, et al. (1998). Immunity. 9:93-103.
Research Articles on BLNK
Precautions
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Products associated with BLNK recombinant protein
Pathways associated with BLNK recombinant protein
Diseases associated with BLNK recombinant protein
Organs/Tissues associated with BLNK recombinant protein
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