NP_001120662
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53.1kDa (473aa)
NCBI Official Full Name
tyrosine-protein kinase CSK
NCBI Official Synonym Full Names
C-terminal Src kinase
NCBI Protein Information
tyrosine-protein kinase CSK
UniProt Protein Name
Tyrosine-protein kinase CSK
UniProt Synonym Protein Names
C-Src kinase; Protein-tyrosine kinase CYL
NCBI Summary for CSK
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
UniProt Comments for CSK
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Product References and Citations for CSK recombinant protein
Braeuninger A., et al. (1991) Proc. Natl. Acad. Sci. u.S.A. 88:10411-10415
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Products associated with CSK recombinant protein
Pathways associated with CSK recombinant protein
Diseases associated with CSK recombinant protein
Organs/Tissues associated with CSK recombinant protein
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