NP_001027539.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
56,885 Da
NCBI Official Full Name
kunitz-type protease inhibitor 1 isoform 2
NCBI Official Synonym Full Names
serine peptidase inhibitor, Kunitz type 1
NCBI Protein Information
kunitz-type protease inhibitor 1
UniProt Protein Name
Kunitz-type protease inhibitor 1
UniProt Synonym Protein Names
Hepatocyte growth factor activator inhibitor type 1; HAI-1
UniProt Synonym Gene Names
NCBI Summary for HAI-1 / SPINT1
The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for HAI-1 / SPINT1
SPINT1: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: extracellular region; extracellular space; membrane
Research Articles on HAI-1 / SPINT1
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Pathways associated with HAI-1 / SPINT1 recombinant protein
Diseases associated with HAI-1 / SPINT1 recombinant protein
Organs/Tissues associated with HAI-1 / SPINT1 recombinant protein
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