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HIV-1 gp120 LAV Recombinant Protein

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Catalog # MBS143214
Unit / Price
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  0.002 mg  /  $140 +1 FREE 8GB USB
  0.01 mg  /  $265 +1 FREE 8GB USB
  0.1 mg  /  $1,815 +2 FREE 8GB USB
HIV-1 gp120 LAV recombinant protein
Product Name

HIV-1 gp120 LAV, Recombinant Protein

Popular Item
Full Product Name

Recombinant HIV-1 gp120 LAV

Product Synonym Names
HIV-1 gp120 LAV; HIV-1 gp120 LAV Envelope Recombinant; HIV-1 gp120 LAV
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
IPGEKLWVTV YYGVPVWKEA TTTLFCASDA KAYDTEVHNV ATHACVPTDP NPQEVVLVNV TENFNMWKND MVEQMHEDII SLWDQSLKPC VKLTPLCVSL KCTDLKNDTN TNSSSGRMIM EKGEIKNCSF NISTSIRDKV QKEYAFFYKL DIVPIDNTSY RLISCNTSVI TQACPKVSFE PIPIHYCAPA GFAILKCNNK TFNGTGPCTN VSTVQCTHGI RPVVSTQLLL NGSLAEEDVV IRSANFTDNA KTIIVQLNTS VEINCTRPNN NTRKSIRIQR GPGRAFVTIG KIGNMRQAHC NISRAKWNAT LKQIASKLRE QFGNNKTIIF KQSSGGDPEI VTHSFNCGGE FFYCNSTQLF NSTWFNSTWS TEGSNNTEGS DTITLPCRIK QFINMWQEVG KAMYAPPISG QIRCSSNITG LLLTRDGGNN NNGSEIFRPG GGDMRDNWRS ELYKYKVVKI EPLGVAPTKA KRRVVQREKR
3D Structure
ModBase 3D Structure for M19921
Host
Baculovirus Insect Cells
Specificity
Immunoreactive with sera from HIV infected individuals. Western blots: 0.1-1.0 ug/strip.
Purity/Purification
Greater than 90.0% as determined by HPLC analysis and SDS-PAGE.
Form/Format
The protein solution contains 10mM Tris-Cl pH-7.6, 150mM NaCl and 0.01% Triton N-101.
Sterile filtered colorless clear solution.
Concentration
10ug/20ul (lot specific)
Other Notes
Small volumes of HIV-1 gp120 LAV recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
HIV-1 gp120 LAV recombinant protein
Description: HIV-1 gp120 LAV isolate Recombinant- is the external envelope protein, full-length 100-120 kDa, derived from the env. gene of HIV-1 and glycosylated with N-linked sugars and produced using baculovirus vectors in insect cells. Purified under conditions that maintain the tertiary structure of the biologically active molecule. HIV-1 gp120 LAV sequence is identical to the predicted amino acid sequence of gp120 from pNL4-3 (Adachi et al. [1986], J. Virol. 59, 284-291; GenBank accession number M19921).

Introduction: Human immunodeficiency virus (HIV) is a retrovirusthat can lead to a condition in which the immune systembegins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the humanimmune systemsuch as helper T cells(specifically CD4+ T cells), macrophagesand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosisin infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytesthat recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunityis lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genomeis converted to double-stranded DNAby a virally encoded reverse transcriptasethat is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integraseso that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latentand the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells.
Applications Tested/Suitable for HIV-1 gp120 LAV recombinant protein
ELISA (EIA), Western Blot (WB)
HIV-1 gp120 antigen is suitable for ELISA and Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems.
NCBI/Uniprot data below describe general gene information for HIV-1 gp120 LAV. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
UniProt Primary Accession #
NCBI Official Full Name
Human immunodeficiency virus type 1, NY5/BRU (LAV-1) recombinant clone pNL4-3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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