NP_002459
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38.7kDa (345aa)
NCBI Official Full Name
myeloid differentiation primary response protein MyD88 isoform 2
NCBI Official Synonym Full Names
myeloid differentiation primary response 88
NCBI Official Synonym Symbols
NCBI Protein Information
myeloid differentiation primary response protein MyD88
UniProt Protein Name
Myeloid differentiation primary response protein MyD88
NCBI Summary for MYD88
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
UniProt Comments for MYD88
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Product References and Citations for MYD88 recombinant protein
Kawai T., et al. (2004) Nat. Immunol A. 5:1061-1068; Semaan N., et al. (2008) J. Immunol. 180:3485-3491
Research Articles on MYD88
Precautions
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Products associated with MYD88 recombinant protein
Pathways associated with MYD88 recombinant protein
Diseases associated with MYD88 recombinant protein
Organs/Tissues associated with MYD88 recombinant protein
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