NP_001013568.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
50,064 Da
NCBI Official Full Name
N-lysine methyltransferase SMYD2-A
NCBI Official Synonym Full Names
SET and MYND domain containing 2a
NCBI Official Synonym Symbols
smyd2; im:7146196; wu:fc02f02; zgc:110553 [Similar Products]
NCBI Protein Information
N-lysine methyltransferase SMYD2-A
UniProt Protein Name
N-lysine methyltransferase SMYD2-A
UniProt Synonym Protein Names
Histone methyltransferase SMYD2-A (EC:2.1.1.43); SET and MYND domain-containing protein 2A
UniProt Synonym Gene Names
UniProt Comments for smyd2a
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860' ().
Research Articles on smyd2a
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Pathways associated with smyd2a recombinant protein
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