Q9I840.1
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UniProt Primary Accession #
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NCBI Official Full Name
Snaclec rhodocytin subunit beta
UniProt Protein Name
Snaclec rhodocytin subunit beta
UniProt Synonym Protein Names
Aggretin beta chain; Rhodoaggretin subunit beta
UniProt Entry Name
SLYB_CALRH
UniProt Comments for Rhodocytin subunit beta
Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLCgamma2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial.
"Molecular cloning and sequence analysis of aggretin, a collagen-like platelet aggregation inducer."
Chung C.-H., Au L.-C., Huang T.-F.
Biochem. Biophys. Res. Commun. 263:723-727(1999)
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