NP_008867.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens small ubiquitin-like modifier 3 (SUMO3), mRNA
NCBI Official Synonym Full Names
small ubiquitin-like modifier 3
NCBI Protein Information
small ubiquitin-related modifier 3; SUMO-2; SMT3 homolog 1; ubiquitin-like protein SMT3A; ubiquitin-like protein SMT3B; SMT3 suppressor of mif two 3 homolog 1; SMT3 suppressor of mif two 3 homolog 3
UniProt Protein Name
Small ubiquitin-related modifier 3
UniProt Synonym Protein Names
SMT3 homolog 1; SUMO-2; Ubiquitin-like protein SMT3B
UniProt Synonym Gene Names
UniProt Entry Name
SUMO3_HUMAN
NCBI Summary for SUMO3
SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002 [PubMed 12383504]).[supplied by OMIM, Mar 2008]
UniProt Comments for SUMO3
Function: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Ref.9 Ref.15
Subunit structure: Covalently attached to a number of proteins
By similarity. Interacts with USP25 (via ts SIM domain); the interaction sumoylates USP25 and inhibits its ubiquitin hydrolyzing activity. Interacts with SAE2 and UBE2I. Ref.9 Ref.11 Ref.15
Subcellular location: Cytoplasm Ref.10.
Tissue specificity: Expressed predominantly in liver. Ref.13
Post-translational modification: Polymeric chains can be formed through Lys-11 cross-linking.Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.
Sequence similarities: Belongs to the ubiquitin family. SUMO subfamily.Contains 1 ubiquitin-like domain.
Caution: Frequently wrongly assigned as SMT3A in many databases and publications. However, according to initial nomenclature, SUMO3 corresponds to SMT3B (Ref.8).
Product References and Citations for SUMO3 recombinant protein
1. Su, H.-L. et.al: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Gene 296: 65-73, 2002. 2. Lapenta, V.et.al: SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. Genomics 40: 362-366, 1997.
Research Articles on SUMO3
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Products associated with SUMO3 recombinant protein
Pathways associated with SUMO3 recombinant protein
Diseases associated with SUMO3 recombinant protein
Organs/Tissues associated with SUMO3 recombinant protein
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