View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant Recombinant Protein Catalog # MBS319401 Unit / Price 0.1 mg / $1,140 +1 FREE 8GB USB 5x0.1 mg / $4,920 +6 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant, Recombinant Protein Full Product Name Human TPO, Recombinant Product Synonym Names Human TPO, Recombinant; Thyroid Peroxidase (TPO) (a.a. 19-846), Recombinant Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Host Host: BaculovirusSource: Recombinant protein expressed in insect cells Specificity Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant Purity/Purification >95% pure (SDS-PAGE). Affinity purification using a monoclonal antibody and ion exchange chromatography Form/Format Affinity Purified, Lyophilized Reconstitute with deionized water. Buffer Lyophilized from 20mM Tris-HCl, pH 8.0 containing 250mM Sodium chloride, 0.1mM KI and 5% D-mannitol Preservative No Preservative Preparation and Storage Store lyophilized product at -20 degree C. After reconstitution, aliquot and store at -70 degree C. Avoid multiple freeze/thaw cycles. ISO Certification Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory. Other Notes Small volumes of Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Product Categories/Family for Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant recombinant protein Purified Autoimmune Reagents Applications Tested/Suitable for Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant recombinant protein ELISA Application Notes for Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant recombinant protein Suitable for use in ELISA and Western blot. SDS-Page of Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant recombinant protein TOP NCBI/Uniprot data below describe general gene information for Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant. It may not necessarily be applicable to this product. NCBI GI # 4261820 TOP NCBI Official Full Name thyroid peroxidase TOP NCBI Summary for Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011] TOP UniProt Comments for Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant TPO: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease. Defects in TPO are the cause of thyroid dyshormonogenesis 2A (TDH2A). A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. Belongs to the peroxidase family. XPO subfamily. 8 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.11.1.8; Membrane protein, integral; Oxidoreductase; Mitochondrial; Amino Acid Metabolism - tyrosineChromosomal Location of Human Ortholog: 2p25Cellular Component: extracellular space; cell surface; mitochondrion; integral to plasma membrane; plasma membraneMolecular Function: peroxidase activity; heme binding; iodide peroxidase activity; calcium ion bindingBiological Process: hydrogen peroxide catabolic process; embryonic hemopoiesis; thyroid hormone generation; response to oxidative stress; hormone biosynthetic processDisease: Thyroid Dyshormonogenesis 2a Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant recombinant protein Reference Product PubMed Publications FLNA recombinant protein >12 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and FLNA Pathways associated with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant recombinant protein Products by Pathway Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Organs/Tissues associated with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant recombinant protein Organ/Tissue Name Pubmed Publications Bone Antibodies >13 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and Bone Connective Tissue Antibodies >4 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and Connective Tissue Heart Antibodies >3 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and Heart Muscle Antibodies >3 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and Muscle Brain Antibodies >3 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and Brain Vascular Antibodies >2 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and Vascular Embryonic Tissue Antibodies >2 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and Embryonic Tissue Ear Antibodies >1 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and Ear Kidney Antibodies >1 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and Kidney Umbilical Cord Antibodies >1 publications with Thyroid peroxidase (TPO) (a.a. 19-846), Recombinant and Umbilical Cord TOP