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Rest recombinant protein :: RE1-silencing transcription factor (Rest) Recombinant Protein

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Catalog # MBS1120363
Unit / Price
  0.05 mg (E-Coli)  /  $470 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $625 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $645 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $690 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $805 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $875 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $975 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $985 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,010 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,040 +1 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,470 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,485 +1 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $1,595 +1 FREE 8GB USB
  1 mg (Baculovirus)  /  $1,970 +2 FREE 8GB USB
Rest recombinant protein
Product Name

RE1-silencing transcription factor (Rest), Recombinant Protein

Full Product Name

Recombinant Rat RE1-silencing transcription factor (Rest), partial

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
981-1059. Partial.
Sequence
EGIHSHDGSD LSDNMSEGSD DSGLHGARPA PQEATSKSGK EGLAVKVTEG EFVCIFCDRS FRKEKDYSKH LNRHLVNVY
3D Structure
ModBase 3D Structure for O54963
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rat
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Rest recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Rest recombinant protein
This gene encodes a transcriptional repressor which represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells, and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described; however, their full length nature has not been determined.
NCBI/Uniprot data below describe general gene information for Rest. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
37,821 Da
NCBI Official Full Name
RE1-silencing transcription factor
NCBI Official Synonym Full Names
RE1-silencing transcription factor
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
RE1-silencing transcription factor
UniProt Protein Name
RE1-silencing transcription factor
UniProt Synonym Protein Names
Neural-restrictive silencer factor
UniProt Gene Name
UniProt Synonym Gene Names
NCBI Summary for Rest
represses transcription of the AMPA receptor (AMPAR) subunit GluR2 and other neural genes [RGD, Feb 2006]
UniProt Comments for Rest
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (PubMed:9454838). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression ().
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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