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RFWD2 recombinant protein :: E3 ubiquitin-protein ligase RFWD2 (RFWD2) Recombinant Protein

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Catalog # MBS1476060
Unit / Price
  0.05 mg (E-Coli)  /  $1,165 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,305 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,560 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $1,570 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,615 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,660 +2 FREE 8GB USB
  0.5 mg (E-Coli)  /  $1,735 +2 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,830 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,340 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,370 +2 FREE 8GB USB
  1 mg (E-Coli)  /  $2,465 +3 FREE 8GB USB
  1 mg (Yeast)  /  $2,765 +3 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,100 +3 FREE 8GB USB
RFWD2 recombinant protein
Product Name

E3 ubiquitin-protein ligase RFWD2 (RFWD2), Recombinant Protein

Popular Item
Also Known As

Recombinant Human E3 ubiquitin-protein ligase RFWD2 (RFWD2)

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS1476060 COA
Sequence Positions
1-731aa, full length protein
Sequence Length
707
Sequence
MSGSRQAGSG SAGTSPGSSA ASSVTSASSS LSSSPSPPSV AVSAAALVSG GVAQAAGSGG LGGPVRPVLV APAVSGSGGG AVSTGLSRHS CAARPSAGVG GSSSSLGSGS RKRPLLAPLC NGLINSYEDK SNDFVCPICF DMIEEAYMTK CGHSFCYKCI HQSLEDNNRC PKCNYVVDNI DHLYPNFLVN ELILKQKQRF EEKRFKLDHS VSSTNGHRWQ IFQDWLGTDQ DNLDLANVNL MLELLVQKKK QLEAESHAAQ LQILMEFLKV ARRNKREQLE QIQKELSVLE EDIKRVEEMS GLYSPVSEDS TVPQFEAPSP SHSSIIDSTE YSQPPGFSGS SQTKKQPWYN STLASRRKRL TAHFEDLEQC YFSTRMSRIS DDSRTASQLD EFQECLSKFT RYNSVRPLAT LSYASDLYNG SSIVSSIEFD RDCDYFAIAG VTKKIKVYEY DTVIQDAVDI HYPENEMTCN SKISCISWSS YHKNLLASSD YEGTVILWDG FTGQRSKVYQ EHEKRCWSVD FNLMDPKLLA SGSDDAKVKL WSTNLDNSVA SIEAKANVCC VKFSPSSRYH LAFGCADHCV HYYDLRNTKQ PIMVFKGHRK AVSYAKFVSG EEIVSASTDS QLKLWNVGKP YCLRSFKGHI NEKNFVGLAS NGDYIACGSE NNSLYLYYKG LSKTLLTFKF DTVKSVLDKD RKEDDTNEFV SAVCWRALPD GESNVLIAAN SQGTIKVLEL V
OMIM
608067
3D Structure
ModBase 3D Structure for Q8NHY2
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Tag Information
Tag type will be determined during the manufacturing process
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of RFWD2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for RFWD2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
14,914 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase RFWD2 isoform b
NCBI Official Synonym Full Names
COP1, E3 ubiquitin ligase
NCBI Official Symbol
NCBI Official Synonym Symbols
RFWD2; RNF200
  [Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase RFWD2
UniProt Protein Name
E3 ubiquitin-protein ligase RFWD2
UniProt Synonym Protein Names
Constitutive photomorphogenesis protein 1 homolog; hCOP1; RING finger and WD repeat domain protein 2; RING finger protein 200; RING-type E3 ubiquitin transferase RFWD2Curated
UniProt Gene Name
RFWD2  [Similar Products]
UniProt Synonym Gene Names
COP1; RNF200; hCOP1  [Similar Products]
UniProt Comments for RFWD2
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. Involved in 14-3-3 protein sigma/SFN ubiquitination and proteasomal degradation, leading to AKT activation and promotion of cell survival. Ubiquitinates MTA1 leading to its proteasomal degradation. Upon binding to TRIB1, ubiquitinates CEBPA, which lacks a canonical COP1-binding motif (Probable).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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