NP_035412.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
261,967 Da
NCBI Official Full Name
proto-oncogene tyrosine-protein kinase ROS
NCBI Official Synonym Full Names
Ros1 proto-oncogene
NCBI Official Synonym Symbols
NCBI Protein Information
proto-oncogene tyrosine-protein kinase ROS
UniProt Protein Name
Proto-oncogene tyrosine-protein kinase ROS
UniProt Synonym Protein Names
Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Receptor tyrosine kinase c-ros oncogene 1; c-Ros receptor tyrosine kinase
UniProt Synonym Gene Names
UniProt Comments for ROS1
ROS: a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. Normally expressed in adult murine and human epithelial cells of the epididymis. Transgenic mice lacking the c-ros gene are infertile. Ectopic expression of c-Ros has been reported in meningiomas and astrocytomas. Is up-regulated in human glioma: 30% of malignant glioma tumors are ROS positive. An oncogenic fusion protein between PIST (aka FIG) and ROS, resulting from an intra-chromosomal homozygous deletion of 240 kilobases on 6q21, is found in glioblastoma multiform. PIST (aka FIG) is a peripheral membrane protein associated with the Golgi apparatus. Unlike other fusion RTK oncogenes, the mechanism of activation of PIST-ROS does not appear to be dimerization: the PIST-ROS fusion protein appears to be monomeric in vivo. Rather, activation of the fused ROS kinase appears to depend upon translocation to the golgi apparatus: deletion of 2nd coiled-coil region of PIST, crucial for Golgi localization, appears to eliminate the transformation capacity of PIST-ROS. c-ROS may also be activated epigenetically, suggesting caution when using 5-aza-dC for treating glioma.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Sev family; TK group
Chromosomal Location of Human Ortholog: 10 B3|10 26.18 cM
Cellular Component: cell surface; integral component of membrane; membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: cell differentiation; cell proliferation; columnar/cuboidal epithelial cell development; negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; phosphorylation; protein amino acid phosphorylation; regulation of cell growth; regulation of ERK1 and ERK2 cascade; regulation of phosphate transport; regulation of TOR signaling; spermatogenesis
Research Articles on ROS1
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Products associated with ROS1 elisa kit
Diseases associated with ROS1 elisa kit
Organs/Tissues associated with ROS1 elisa kit
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