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RQCD1 recombinant protein

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Catalog # MBS203971
Unit / Price
  0.1 mg  /  $310 +1 FREE 8GB USB
  0.5 mg  /  $720 +1 FREE 8GB USB
SDS-Page
Product Name

RQCD1, Recombinant Protein

Full Product Name

RQCD1, 1-299aa, Human, His tag, E Coli

Product Synonym Names
Cell differentiation protein RCD1 homolog; Cell differentiation protein RCD1 homolog; CNOT9; CT129; RCD1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHHHHH SSGLVPRGSH MHSLATAAPV PTTLAQVDRE KIYQWINELS SPETRENALL ELSKKRESVP DLAPMLWHSF GTIAALLQEI VNIYPSINPP TLTAHQSNRV CNALALLQCV ASHPETRSAF LAAHIPLFLY PFLHTVSKTR PFEYLRLTSL GVIGALVKTD EQEVINFLLT TEIIPLCLRI MESGSELSKT VATFILQKIL LDDTGLAYIC QTYERFSHVA MILGKMVLQL SKEPSARLLK HVVRCYLRLS DNPRAREALR QCLPDQLKDT TFAQVLKDDT TTKRWLAQLV KNLQEGQVTD PRGIPLPPQ
OMIM
D87957 Genomic DNA
3D Structure
ModBase 3D Structure for Q92600
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% glycerol
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of RQCD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RQCD1 recombinant protein
RQCD1, also known as RCD1, is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation. It down-regulates MYB- and JuN-dependent transcription and may play a role in cell differentiation. RQCD1 also plays a role in retinoic acid-controlled lung development. Recombinant human RQCD1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
Applications Tested/Suitable for RQCD1 recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for RQCD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35.7 kDa (319aa) confirmed by MALDI-TOF
NCBI Official Full Name
CCR4-NOT transcription complex subunit 9 isoform 2
NCBI Official Synonym Full Names
CCR4-NOT transcription complex subunit 9
NCBI Official Symbol
CNOT9  [Similar Products]
NCBI Official Synonym Symbols
RCD1; CAF40; CT129; RCD-1; RQCD1
  [Similar Products]
NCBI Protein Information
CCR4-NOT transcription complex subunit 9; cell differentiation protein RCD1 homolog
UniProt Protein Name
CCR4-NOT transcription complex subunit 9
UniProt Synonym Protein Names
Cell differentiation protein RQCD1 homolog; Rcd-1
UniProt Gene Name
CNOT9  [Similar Products]
UniProt Synonym Gene Names
Rcd-1  [Similar Products]
NCBI Summary for RQCD1
This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]
UniProt Comments for RQCD1
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
Product References and Citations for RQCD1 recombinant protein
Garapaty S., et al. (2008) J Biol Chem. 283 (11):6806-16.; Hiroi N., et al. (2002) EMBO J. 21 (19):5235-44.;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Diseases associated with RQCD1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with RQCD1 and Inflammation
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