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RRM2 recombinant protein

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Catalog # MBS203601
Unit / Price
  0.1 mg  /  $285 +1 FREE 8GB USB
  0.5 mg  /  $640 +1 FREE 8GB USB
SDS-Page
Product Name

RRM2, Recombinant Protein

Also Known As

RRM2, 1-389aa, Human, His tag, E Coli

Product Synonym Names
Ribonucleoside-diphosphate reductase subunit M2; R2; RR2; RR2M; Ribonucleoside-diphosphate reductase subunit M2 Ribonucleotide reductase M2 subunit; Ribonucleotide reductase small subunit
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
389
Sequence
MGSSHHHHHH SSGLVPRGSH MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN FFEKRVGEYQ RMGVMSSPTE NSFTLDADF
OMIM
X59618 mRNA
3D Structure
ModBase 3D Structure for P31350
Host
E Coli
Purity/Purification
> 85% by SDS-PAGE
Form/Format
Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.1M NaCl
Concentration
1.0 mg/ml (determined by Bradford assay) (lot specific)
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of RRM2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RRM2 recombinant protein
RRM2, also known as ribonucleotide reductase M2, is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. This protein plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. Recombinant human RRM2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques
Product Categories/Family for RRM2 recombinant protein
Applications Tested/Suitable for RRM2 recombinant protein
SDS-PAGE

NCBI/Uniprot data below describe general gene information for RRM2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47.0 kDa (409aa) confirmed by MALDI-TOF
NCBI Official Full Name
ribonucleoside-diphosphate reductase subunit M2 isoform 2
NCBI Official Synonym Full Names
ribonucleotide reductase regulatory subunit M2
NCBI Official Symbol
NCBI Official Synonym Symbols
R2; RR2; RR2M
  [Similar Products]
NCBI Protein Information
ribonucleoside-diphosphate reductase subunit M2
UniProt Protein Name
Ribonucleoside-diphosphate reductase subunit M2
UniProt Synonym Protein Names
Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit
UniProt Gene Name
UniProt Synonym Gene Names
NCBI Summary for RRM2
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
UniProt Comments for RRM2
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Product References and Citations for RRM2 recombinant protein
Torrents E, et al. (2002) J Mol Evol. 55 (2):138-52; Herrick J,et al. (2007) Mol Microbiol. 63 (1):22-34;

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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