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RSPO1 recombinant protein :: R-spondin-1 (RSPO1) Recombinant Protein

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Catalog # MBS1449234
Unit / Price
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  0.05 mg (E-Coli)  /  $645 +1 FREE 8GB USB
  0.05 mg (Yeast)  /  $765 +1 FREE 8GB USB
  0.2 mg (E-Coli)  /  $865 +1 FREE 8GB USB
  0.5 mg (E-Coli)  /  $955 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $995 +1 FREE 8GB USB
  0.2 mg (Yeast)  /  $1,035 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,175 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,240 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,435 +1 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,440 +1 FREE 8GB USB
  1 mg (Yeast)  /  $1,860 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $1,880 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,015 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $2,920 +3 FREE 8GB USB
RSPO1 recombinant protein
Product Name

R-spondin-1 (RSPO1), Recombinant Protein

Full Product Name

Recombinant Human R-spondin-1 (RSPO1)

Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
21-263aa, Full Length of Mature Protein
Sequence
SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCKEGLYL HKGRCYPACP EGSSAANGTM ECSSPAQCEM SEWSPWGPCS KKQQLCGFRR GSEERTRRVL HAPVGDHAAC SDTKETRRCT VRRVPCPEGQ KRRKGGQGRR ENANRNLARK ESKEAGAGSR RRKGQQQQQQ QGTVGPLTSA GPA
OMIM
609595
3D Structure
ModBase 3D Structure for Q2MKA7
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of RSPO1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RSPO1 recombinant protein
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
NCBI/Uniprot data below describe general gene information for RSPO1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,775 Da
NCBI Official Full Name
R-spondin-1 isoform 1
NCBI Official Synonym Full Names
R-spondin 1
NCBI Official Symbol
RSPO1  [Similar Products]
NCBI Official Synonym Symbols
RSPO; CRISTIN3
  [Similar Products]
NCBI Protein Information
R-spondin-1
UniProt Protein Name
R-spondin-1
UniProt Synonym Protein Names
Roof plate-specific spondin-1; hRspo1
Protein Family
UniProt Gene Name
RSPO1  [Similar Products]
UniProt Synonym Gene Names
hRspo1  [Similar Products]
NCBI Summary for RSPO1
This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
UniProt Comments for RSPO1
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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