P53350.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,255 Da
NCBI Official Full Name
Serine/threonine-protein kinase PLK1
NCBI Official Synonym Full Names
polo-like kinase 1
NCBI Official Synonym Symbols
NCBI Protein Information
serine/threonine-protein kinase PLK1; PLK-1; polo like kinase; polo (Drosophia)-like kinase; serine/threonine-protein kinase 13; cell cycle regulated protein kinase
UniProt Protein Name
Serine/threonine-protein kinase PLK1
UniProt Synonym Protein Names
Polo-like kinase 1; PLK-1; Serine/threonine-protein kinase 13
UniProt Synonym Gene Names
UniProt Entry Name
PLK1_HUMAN
NCBI Summary for SA
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
UniProt Comments for SA
PLK1: a kinase of the PLK family. Contains a polo-box domain (PBD), a specific phosphoserine or phosphothreonine binding domain. Substrates include BRCA2, Myt1, NudC, Cdc25C, cyclin B1, Nlp and other mitotic proteins. Inhibited by ATR. Plays a role in regulation of cytokinesis and coordinating M-phase events.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.21; Other group; PLK family
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component: kinetochore; microtubule cytoskeleton; nucleoplasm; spindle pole; centrosome; spindle microtubule; cytoplasm; nucleolus; spindle; spindle midzone; midbody; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; microtubule binding; kinase activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of cell cycle; positive regulation of proteolysis; regulation of mitotic cell cycle; mitotic nuclear envelope disassembly; protein ubiquitination; cytokinesis; anaphase-promoting complex activation during mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; response to antibiotic; establishment of protein localization; cytokinesis after mitosis; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; centrosome organization and biogenesis; positive regulation of ubiquitin-protein ligase activity; mitotic cell cycle spindle assembly checkpoint; G2/M transition of mitotic cell cycle; mitosis; mitotic sister chromatid segregation; protein destabilization; organelle organization and biogenesis; regulation of mitotic metaphase/anaphase transition; negative regulation of cyclin-dependent protein kinase activity; cell proliferation; peptidyl-serine phosphorylation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of protein binding; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; polar body extrusion after meiotic divisions; mitotic cell cycle; G2/M transition DNA damage checkpoint; mitotic metaphase/anaphase transition; microtubule bundle formation; negative regulation of apoptosis
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