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SAP protein :: Serum Amyloid P Protein

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Catalog # MBS173186
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SAP protein
Product Name

Serum Amyloid P (SAP), Protein

Popular Item
Also Known As

Serum Amyloid P (SAP), Human

Product Synonym Names
Serum Amyloid P (SAP)
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
223
OMIM
104770
Form/Format
Liquid
Source
Human Serum
UNSPSC Code
51131907
Recertification
2 years
Preparation and Storage
2-8 degree C
Other Notes
Small volumes of SAP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SAP protein
Custom preparations, technical support, bulk quantities and aliquoting available.

Human Serum Amyloid P is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. SAP has a pentagonal structure and modulates immunologic responses in man, inhibits elastase and has been suggested as an indicator of liver disease and has 51% sequence homology with C-reactive protein (CRP).
NCBI/Uniprot data below describe general gene information for SAP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Related Accession #
Molecular Weight
250 kDa
NCBI Official Full Name
serum amyloid P-component
NCBI Official Synonym Full Names
amyloid P component, serum
NCBI Official Symbol
NCBI Official Synonym Symbols
SAP; PTX2; HEL-S-92n
  [Similar Products]
NCBI Protein Information
serum amyloid P-component; pentaxin-related; 9.5S alpha-1-glycoprotein; epididymis secretory sperm binding protein Li 92n
UniProt Protein Name
Serum amyloid P-component
UniProt Synonym Protein Names
9.5S alpha-1-glycoproteinSerum amyloid P-component(1-203)
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
PTX2; SAP  [Similar Products]
UniProt Entry Name
SAMP_HUMAN
NCBI Summary for SAP
The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
UniProt Comments for SAP
APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.

Protein type: Secreted; Secreted, signal peptide; Chaperone

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; protein complex; extracellular region; nucleus

Molecular Function: complement component C1q binding; unfolded protein binding; virion binding; calcium ion binding; carbohydrate binding

Biological Process: protein folding; negative regulation of virion penetration into host cell; acute-phase response; negative regulation of acute inflammatory response; innate immune response; chaperone-mediated protein complex assembly; negative regulation of monocyte differentiation; negative regulation of viral reproduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with SAP protein
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