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SAR1A recombinant protein :: GTP-Binding Protein SAR1A Recombinant Protein

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Catalog # MBS143823
Unit / Price
  0.005 mg  /  $140 +1 FREE 8GB USB
  0.02 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,665 +3 FREE 8GB USB
SAR1A recombinant protein
Product Name

GTP-Binding Protein SAR1A, Recombinant Protein

Also Known As

Recombinant Human GTP-Binding Protein SAR1A

Product Synonym Names
SAR1A Human; GTP-Binding Protein SAR1A Human Recombinant; GTP-binding protein SAR1a; COPII-associated small GTPase; SAR1A; SAR1; SARA; SARA1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
198
Sequence
MGSSHHH HHH SSGLVPRGSH MSFIFEWIYN GFSSVLQFLG LYKKSGKLVF LGLDNAGKTT LLHMLKDDRL GQHVPTLHPT SEELTIAGMT FTTFDLGGHE QARRVWKNYL PAINGIVFLV DCADHSRLVE SKVELNALMT DETISNVPIL ILGNKIDRTD AISEEKLREI FGLYGQTTGK GNVTLKELNA RPMEVFMCSV LKRQGYGEGF RWLSQYID
OMIM
607691
3D Structure
ModBase 3D Structure for Q9NR31
Host
E Coli
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
The SAR1A solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT and 10% glycerol.
Sterile Filtered colorless solution.
Preparation and Storage
SAR1A although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Other Notes
Small volumes of SAR1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SAR1A recombinant protein
Description: SAR1A Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 218 amino acids (1- 198 a.a.) and having a molecular mass of 24.5kDa.The SAR1A is purified by proprietary chromatographic techniques.

Introduction: SAR1A is a member of the small GTPase superfamily. SAR1A is a vital component of COPII vesicle coats involved in export of cargo from the ER (Endoplasmic Reticulum). The GTPase activity of SAR1A serves as a molecular switch to control protein-protein and protein-lipid interactions which dictate vesicle budding from the ER. SAR1A, while GDP-bound interacts with the membrane-bound exchange factor Sec12 and trades its bound GDP for GTP. SAR1A is also involved in the transport from the ER to the Golgi apparatus. SAR1A is required to maintain SEC16A localization at distinct locations on the ER membrane possibly by preventing its dissociation. SAR1A-GTP-dependent compilation of SEC16A on the ER membrane creates a structured scaffold defining endoplasmic reticulum exit sites.
NCBI/Uniprot data below describe general gene information for SAR1A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,500 Da
NCBI Official Full Name
GTP-binding protein SAR1a
NCBI Official Synonym Full Names
secretion associated, Ras related GTPase 1A
NCBI Official Symbol
SAR1A  [Similar Products]
NCBI Official Synonym Symbols
SAR1; Sara; SARA1; masra2
  [Similar Products]
NCBI Protein Information
GTP-binding protein SAR1a; COPII-associated small GTPase; SAR1 gene homolog A; SAR1 homolog A; SAR1a gene homolog 1
UniProt Protein Name
GTP-binding protein SAR1a
UniProt Synonym Protein Names
COPII-associated small GTPase
Protein Family
UniProt Gene Name
SAR1A  [Similar Products]
UniProt Synonym Gene Names
SAR1; SARA; SARA1  [Similar Products]
UniProt Entry Name
SAR1A_HUMAN
UniProt Comments for SAR1A
SAR1A: Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). Belongs to the small GTPase superfamily. SAR1 family.

Protein type: G protein, monomeric; G protein, monomeric, SAR1; G protein

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: Golgi apparatus; sarcoplasmic reticulum

Molecular Function: GTP binding

Biological Process: vesicle-mediated transport; intracellular protein transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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