NP_002961.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
20,024 Da
NCBI Official Full Name
diamine acetyltransferase 1
NCBI Official Synonym Full Names
spermidine/spermine N1-acetyltransferase 1
NCBI Official Synonym Symbols
SAT; DC21; KFSD; SSAT; KFSDX; SSAT-1 [Similar Products]
NCBI Protein Information
diamine acetyltransferase 1; putrescine acetyltransferase; diamine N-acetyltransferase 1; polyamine N-acetyltransferase 1; spermidine/spermine N1-acetyltransferase alpha
UniProt Protein Name
Diamine acetyltransferase 1
UniProt Synonym Protein Names
Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; Spermidine/spermine N(1)-acetyltransferase 1; SSAT; SSAT-1
UniProt Synonym Gene Names
UniProt Entry Name
SAT1_HUMAN
NCBI Summary for SAT1
The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Comments for SAT1
SAT: Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine. Defects in SAT1 may be a cause of keratosis follicularis spinulosa decalvans X-linked (KFSDX). A rare disorder affecting the skin and the eye. Affected men show thickening of the skin of the neck, ears, and extremities, especially the palms and soles, loss of eyebrows, eyelashes and beard, thickening of the eyelids with blepharitis and ectropion, and corneal degeneration. Belongs to the acetyltransferase family.
Protein type: EC 2.3.1.57; Acetyltransferase; Amino Acid Metabolism - arginine and proline
Chromosomal Location of Human Ortholog: Xp22.1
Cellular Component: intracellular; cytosol
Molecular Function: protein binding; diamine N-acetyltransferase activity; spermidine binding
Biological Process: spermidine acetylation; polyamine biosynthetic process; angiogenesis; putrescine catabolic process; regulation of cell proliferation; polyamine metabolic process
Disease: Keratosis Follicularis Spinulosa Decalvans, X-linked
Research Articles on SAT1
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Products associated with SAT1 elisa kit
Pathways associated with SAT1 elisa kit
Diseases associated with SAT1 elisa kit
Organs/Tissues associated with SAT1 elisa kit
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