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SDHC cdna clone

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Catalog # MBS1270166
Unit / Price
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
SDHC cdna clone
Product Name

SDHC, cDNA Clone

Full Product Name

SDHC cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggctgcgc tgttgctgag acacgttggt cgtcattgcc tccgagccca ctttagccct cagctctgta tcagaaatgc tgttcctttg ggaaccacgg ccaaagaaga gatggagcgg ttctggaata agaatatagg ttcaaaccgt cctctgtctc cccacattac tatctacagt tggtctcttc ccatggcgat gtccatctgc caccgtggca ctggtattgc tttgagtgca ggggtctctc tttttggcat gtcggccctg ttactccctg ggaactttga gtcttatttg gaacttgtga agtccctgtg tctggggcca gcactgatcc acacagctaa gtttgcactt gtcttccctc tcatgtatca tacctggaat gggatccgac acttgatgtg ggacctagga aaaggcctga agattcccca gctataccag tctggagtgg ttgtcctggt tcttactgtg ttgtcctcta tggggctggc agccatgtga
OMIM
602413
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of SDHC cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SDHC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,474 Da
NCBI Official Full Name
Homo sapiens succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa, mRNA
NCBI Official Synonym Full Names
succinate dehydrogenase complex subunit C
NCBI Official Symbol
NCBI Official Synonym Symbols
CYBL; PGL3; QPS1; SDH3; CYB560
  [Similar Products]
NCBI Protein Information
succinate dehydrogenase cytochrome b560 subunit, mitochondrial
UniProt Protein Name
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
UniProt Synonym Protein Names
Integral membrane protein CII-3; QPs-1; QPs1; Succinate dehydrogenase complex subunit C; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL
UniProt Gene Name
UniProt Synonym Gene Names
CYB560; SDH3; QPs1; CYBL  [Similar Products]
UniProt Entry Name
C560_HUMAN
NCBI Summary for SDHC
This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]
UniProt Comments for SDHC
SDHC: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHC are the cause of paragangliomas type 3 (PGL3). A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas are most commonly located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear. Defects in SDHC are a cause of paraganglioma and gastric stromal sarcoma (PGGSS); also known as Carney- Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance. Belongs to the cytochrome b560 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex II; mitochondrion

Molecular Function: heme binding

Biological Process: aerobic respiration; mitochondrial electron transport, succinate to ubiquinone; tricarboxylic acid cycle

Disease: Gastrointestinal Stromal Tumor; Paraganglioma And Gastric Stromal Sarcoma; Paragangliomas 3
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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