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SDHD elisa kit :: Rat succinate dehydrogenase complex, subunit D, integral membrane protein ELISA Kit

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Catalog # MBS9332735
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SDHD elisa kit
Product Name

succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD), ELISA Kit

Full Product Name

Rat Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, SDHD ELISA Kit

Product Synonym Names
Rat Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; mitochondrial (SDHD) ELISA kit; CBT1; PGL; PGL1; SDH4; succinate dehydrogenase complex; subunit D; succinate dehydrogenase ubiquinone cytochrome B small subunit; succinate dehydrogenase complex; subunit D; integral membrane protein
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
3D Structure
ModBase 3D Structure for Q6PCT8
Species Reactivity
Preparation and Storage
Store all reagents at 2-8 degree C
Product Note
Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of SDHD elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for SDHDpurchase
MBS9332735 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SDHD. The ELISA analytical biochemical technique of the MBS9332735 kit is based on SDHD antibody-SDHD antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SDHD antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SDHD. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
NCBI/Uniprot data below describe general gene information for SDHD. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
16,976 Da
NCBI Official Full Name
succinate dehydrogenase
NCBI Official Synonym Full Names
succinate dehydrogenase complex, subunit D, integral membrane protein
NCBI Official Symbol
NCBI Protein Information
succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; QPs3; cybS; CII-4; succinate dehydrogenase complex subunit D; succinate-ubiquinone reductase membrane anchor subunit; succinate-ubiquinone oxidoreductase cytochrome b small subunit
UniProt Protein Name
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
UniProt Synonym Protein Names
CII-4; QPs3; Succinate dehydrogenase complex subunit D; Succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
DHSD_RAT
NCBI Summary for SDHD
human homolog is a subunit of succinate-ubiquinone oxidoreductase, which plays a role in mitochondrial electron transport [RGD, Feb 2006]
UniProt Comments for SDHD
SDHD: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHD are a cause of paragangliomas type 1 (PGL1). A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. PGL1 is a rare autosomal dominant disorder which is characterized by the development of mostly benign, highly vascular, slowly growing tumors in the head and neck. In the head and neck region, the carotid body is the largest of all paraganglia and is also the most common site of the tumors. Defects in SDHD are a cause of susceptibility to pheochromocytoma (PCC). A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. Defects in SDHD may be a cause of susceptibility to intestinal carcinoid tumor (ICT). A yellow, well- differentiated, circumscribed tumor that arises from enterochromaffin cells in the small intestine or, less frequently, in other parts of the gastrointestinal tract. Defects in SDHD are a cause of paraganglioma and gastric stromal sarcoma (PGGSS); also called Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance. Defects in SDHD are a cause of Cowden-like syndrome (CWDLS). Cowden-like syndrome is a cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus. Belongs to the CybS family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Carbohydrate Metabolism - citrate (TCA) cycle; Energy Metabolism - oxidative phosphorylation; Mitochondrial

Cellular Component: mitochondrial envelope; mitochondrial respiratory chain complex II; mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: ubiquinone binding; metal ion binding; heme binding; succinate dehydrogenase activity

Biological Process: tricarboxylic acid cycle; regulation of catecholamine secretion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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