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SELE western blot control :: E-Selectin Western Blot Control

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Catalog # MBS343017
Unit / Price
  0.01 mg  /  $225 +1 FREE 8GB USB
SELE western blot control
Product Name

E-Selectin, Western Blot Control

Also Known As

E-Selectin (Western Blot Control)

Product Synonym Names
Endothelial leukocyte adhesion molecule 1; ELAM1; ELAM
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
610
OMIM
131210
3D Structure
ModBase 3D Structure for P16581
Purity/Purification
>= 95% (SDS PAGE)
Form/Format
Liquid
Buffer
Buffered 50% glycerol
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SELE western blot control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SELE western blot control
E-selectin belongs to a family of divalent cation dependent carbohydrate-binding glycoproteins or adhesion molecules. E-selectin is expressed on the surface of endothelial cells and mediates the interaction of leukocytes and platelets with endothelial cells during an inflammatory response. Recombinant human E-selectin comprises a 379 amino acid fragment (179-557) corresponding to the cysteine rich complement control region and is expressed in E Coli with an amino-terminal hexahistidine tag. This product not intended for therapeutic use.
NCBI/Uniprot data below describe general gene information for SELE. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,655 Da[Similar Products]
NCBI Official Full Name
E-selectin
NCBI Official Synonym Full Names
selectin E
NCBI Official Symbol
NCBI Official Synonym Symbols
ELAM; ESEL; CD62E; ELAM1; LECAM2
  [Similar Products]
NCBI Protein Information
E-selectin
UniProt Protein Name
E-selectin
UniProt Synonym Protein Names
CD62 antigen-like family member E; Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD_antigen: CD62E
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ELAM1; ELAM-1; LECAM2  [Similar Products]
UniProt Entry Name
LYAM2_HUMAN
NCBI Summary for SELE
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
UniProt Comments for SELE
SELE: Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. Belongs to the selectin/LECAM family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q22-q25

Cellular Component: caveola; coated pit; cortical cytoskeleton; extracellular space; lipid raft; perinuclear region of cytoplasm; plasma membrane

Molecular Function: phospholipase binding; protein binding; sialic acid binding; transmembrane receptor activity

Biological Process: actin filament-based process; calcium-mediated signaling; heterophilic cell adhesion; inflammatory response; leukocyte adhesion; leukocyte migration; leukocyte migration during inflammatory response; leukocyte tethering or rolling; phospholipase C activation; positive regulation of receptor internalization; regulation of inflammatory response; response to lipopolysaccharide

Disease: Hypertension, Essential
Product References and Citations for SELE western blot control
Lobb R.R. et al. (1991) J. Immunol. 147 (1): 124-129. Li S.H. et al., (1994) J. Biol. Chem. 269 (6): 4431-4437

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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