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SELPLG recombinant protein :: Selectin P Ligand Recombinant Protein

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Catalog # MBS146316
Unit / Price
  0.002 mg  /  $140 +1 FREE 8GB USB
  0.01 mg  /  $205 +1 FREE 8GB USB
  0.1 mg  /  $1,220 +1 FREE 8GB USB
SELPLG recombinant protein
Product Name

Selectin P Ligand (SELPLG), Recombinant Protein

Popular Item
Also Known As

Recombinant Human Selectin P Ligand

Product Synonym Names
Cutaneous Lymphocyte-Associated Associated Antigen, Selectin P Ligand, PSGL-1, CD162 Antigen, P-Selectin Glycoprotein Ligand 1, CLA
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
402
Sequence
MGSSHHH HHH SSGLVPRGSH MGSQAT EYEY LDYDFLPETE PPEMLRNSTD TTPLTGPGTP ESTTVEPAAR RSTGLDAGGA VTELTTELAN MGNLSTDSAA MEI
OMIM
600738
Purity/Purification
Greater than 80% as determined by SDS-PAGE.
Form/Format
The SELPLG solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
Concentration
0.25mg/ml (lot specific)
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Preparation and Storage
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of SELPLG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SELPLG recombinant protein
Introduction:
SELPLG glycoprotein functions as a high affinity counter-receptor for the cell adhesion selectin molecules (P, E and L) located in stimulated T lymphocytes and myeloid cells. SELPLG binds leukocytes to activated platelets or endothelia expressing selectins, a vital role in leukocyte trafficking throughout inflammation. In order to have a high-affinity binding activity SELPLG needs two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans. Polymorphisms and abnormal expression of SELPLG are linked to defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.
Description:
SELPLG Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 103 amino acids (42-121) and having a molecular mass of 10.9 kDa (Molecular size on SDS-PAGE will appear higher). SELPLG is fused to a 23 amino acid His-tag at N-terminus.
NCBI/Uniprot data below describe general gene information for SELPLG. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Selectin P ligand
NCBI Official Synonym Full Names
selectin P ligand
NCBI Official Symbol
SELPLG  [Similar Products]
NCBI Official Synonym Symbols
CLA; CD162; PSGL1; PSGL-1
  [Similar Products]
NCBI Protein Information
P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen
UniProt Protein Name
P-selectin glycoprotein ligand 1
UniProt Synonym Protein Names
Selectin P ligand; CD_antigen: CD162
UniProt Gene Name
SELPLG  [Similar Products]
UniProt Synonym Gene Names
PSGL-1  [Similar Products]
UniProt Entry Name
SELPL_HUMAN
NCBI Summary for SELPLG
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
UniProt Comments for SELPLG
SELPLG: A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor binding

Biological Process: cell adhesion; blood coagulation; leukocyte tethering or rolling; leukocyte migration; leukocyte adhesive activation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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