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SEMA3A recombinant protein :: Semaphorin 3A Recombinant Protein

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Catalog # MBS692128
Unit / Price
  0.005 mg  /  $200 +1 FREE 8GB USB
  0.025 mg  /  $340 +1 FREE 8GB USB
SEMA3A recombinant protein
Product Name

Semaphorin 3A (SEMA3A), Recombinant Protein

Popular Item
Also Known As

Human Semaphorin 3A

Product Synonym Names
SEMA3A; SEMAD
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Length
771
Sequence
NYQNGKNNVP RLKLSYKEML ESNNVITFNG LANSSSYHTF LLDEER SRLY VGAKDHIFSF DLVNIKDFQK IVWPVSYTRR DECKWAGKDI L KECANFIKV LKAYNQTHLY ACGTGAFHPI CTYIEIGHHP EDNIFKL ENS HFENGRGKSP YDPKLLTASL LIDGELYSGT AADFMGRDFA IF RTLGHHHP IRTEQHDSRW LNDPKFISAH LISESDNPED DKVYFFFR EN AIDGEHSGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LIC SVPGPNG IDTHFDELQD VFLMNFKDPK NPVVYGVFTT SSNIFKGSA V CMYSMSDVRR VFLGPYAHRD GPNYQWVPYQ GRVPYPRPGT CPSK TFGGFD STKDLPDDVI TFARSHPAMY NPVFPMNNRP IVIKTDVNYQ FTQIVVDRVD AEDGQYDVMF IGTDVGTVLK VVSIPKETWY DLEEV LLEEM TVFREPTAIS AMELSTKQQQ LYIGSTAGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS ACSRYFPTAK RRTRRQDIRN GDPLTH CSDL HHDNHHGHSP EERIIYGVEN SSTFLECSPK SQRALVYWQF Q RRNEERKEE IRVDDHIIRT DQGLLLRSLQ QKDSGNYLCH AVEHGFI QTL LKVTLEVIDT EHLEELLHKD DDGDGSKTKE MSNSMTPSQK VW YRDFMQLI NHPNLNTMDE FCEQVWKRDR KQRRQRPGHT PGNSNKWK HL QENKKGRNRR THEFERAPRS V
Chromosome Location
Chromosome: 7; NC_000007.14 (83958343..84492768, complement). Location: 7p12.1
OMIM
603961
3D Structure
ModBase 3D Structure for Q14563
Host
CHO Cells
Species Reactivity
Human
Purity/Purification
> 95% by SDS-PAGE & HPLC analyses
Form/Format
Lyophilized from 20mM Tris, pH 8.0
Endotoxin level
<0.1 ng per ug of Semaphorin 3A
Biological Activity
Determined by its ability to bind recombinant rat Neuropilin-1 Fc Chimera in a functional ELISA assay.
Reconstitution
Reconstituted in water to a concentration of 0.1-1.0 mg/ml. Do not vortex! For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.
Preparation and Storage
The lyophilized protein is stable for 1 month at room temperature and 6 months at 4 degree C, but best stored at -20 degree C. Reconstituted human Semaphorin 3A is stable for 1 week at 2 degree C to 8 degree C and 3 months at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of SEMA3A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SEMA3A recombinant protein
Semaphorins are a large group of structurally related secreted, GPI-anchored and transmembrane cell signaling molecules. There are 8 major classifications (1-7) of Semaphorins characterized by the existence of a conserved 500 amino acid SEMA domain at the amino terminus. Classes 3,4,6, and 7 are found in vertebrates only, whilst class 5 is found in both vertebrates and invertebrates. Each class is then divided into additional subgroups based on shared structural characteristics. Semaphorins primarily function as axon growth cone guidance factors during neuronal development. Semaphorin 3A acts as a chemo-repellent to axons, and an inhibitor of the growth of axons by signaling through receptors, Neuropilin-1and Plexin-A. Recombinant human Semaphorin 3A is a 751 amino acid protein containing the SEMA domain, an immunoglobulin c2-like domain and a basic domain (Arg/Lys rich) near the C-terminus.
NCBI/Uniprot data below describe general gene information for SEMA3A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
semaphorin-3A
NCBI Official Synonym Full Names
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
NCBI Official Symbol
SEMA3A  [Similar Products]
NCBI Official Synonym Symbols
HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III
  [Similar Products]
NCBI Protein Information
semaphorin-3A; collapsin 1; semaphorin D; semaphorin L; semaphorin III
UniProt Protein Name
Semaphorin-3A
UniProt Synonym Protein Names
Semaphorin III
Protein Family
UniProt Gene Name
SEMA3A  [Similar Products]
UniProt Synonym Gene Names
SEMAD; Sema III  [Similar Products]
UniProt Entry Name
SEM3A_HUMAN
NCBI Summary for SEMA3A
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]
UniProt Comments for SEMA3A
Function: Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. Ref.3

Subunit structure: Interacts with PLXND1

By similarity.

Subcellular location: Secreted

By similarity.

Domain: Strong binding to neuropilin is mediated by the carboxy third of the protein.

Involvement in disease: Hypogonadotropic hypogonadism 16 with or without anosmia (HH16) [MIM:614897]: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).Note: The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Ref.3 Ref.6

Sequence similarities: Belongs to the semaphorin family.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 PSI domain.Contains 1 Sema domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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