NP_002630.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,763 Da
NCBI Official Full Name
serpin B5
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade B (ovalbumin), member 5
NCBI Official Synonym Symbols
NCBI Protein Information
serpin B5; PI-5; peptidase inhibitor 5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
UniProt Protein Name
Serpin B5
UniProt Synonym Protein Names
Maspin; Peptidase inhibitor 5; PI-5
UniProt Synonym Gene Names
UniProt Entry Name
SPB5_HUMAN
UniProt Comments for SERPINB5
maspin: Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 18q21.33
Cellular Component: extracellular space; cytoplasm
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding
Biological Process: extracellular matrix organization and biogenesis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation
Research Articles on SERPINB5
Precautions
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Products associated with SERPINB5 recombinant protein
Pathways associated with SERPINB5 recombinant protein
Diseases associated with SERPINB5 recombinant protein
Organs/Tissues associated with SERPINB5 recombinant protein
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