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SERPINC1 native protein :: Antithrombin III Native Protein

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Catalog # MBS318172
Unit / Price
  0.1 mg  /  $205 +1 FREE 8GB USB
SERPINC1 native protein
Product Name

Antithrombin III (SERPINC1), Native Protein

Full Product Name

Human Plasma Antithrombin III

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (173872942..173886516, complement). Location: 1q23-q25.1
OMIM
107300
3D Structure
ModBase 3D Structure for P01008
Host
Human Plasma
Specificity
Antithrombin III
Purity/Purification
>95% pure (SDS-PAGE)
Form/Format
Purified, Lyophilized.
Reconstitute with 81.3ul distilled water.
Concentration
1.23mg/ml (prior to lyophilization) (lot specific)
Inactivation
Not applicable.
Buffer
Lyophilized from 50mM Tris-HCl, pH 8.0 containing 150mM Sodium chloride
Preservative
No
Lyophilized
Yes
Warnings
All human source materials have tested negative for HIV1, HIV2 and non-reactive for HCV and HBc antibodies and HBsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be consi
Preparation and Storage
Store at -20 degree C. Avoid multiple freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of SERPINC1 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SERPINC1 native protein
Antithrombin III is found in normal serum at 15mg/100ml. Found at higher levels in plasma than in serum because of complexing with thrombin during coagulation. Functions in the inhibition of the proteolytic enzymes involved in blood coagulation and fibrin
Applications Tested/Suitable for SERPINC1 native protein
IEP
NCBI/Uniprot data below describe general gene information for SERPINC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,602 Da[Similar Products]
NCBI Official Full Name
antithrombin III
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade C (antithrombin), member 1
NCBI Official Symbol
SERPINC1  [Similar Products]
NCBI Official Synonym Symbols
AT3; ATIII; MGC22579
  [Similar Products]
NCBI Protein Information
antithrombin-III; serpin C1; antithrombin III; OTTHUMP00000035393; serine-cysteine proteinase inhibitor clade C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
UniProt Protein Name
Antithrombin-III
UniProt Synonym Protein Names
Serpin C1
Protein Family
UniProt Gene Name
SERPINC1  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
ANT3_HUMAN
NCBI Summary for SERPINC1
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq]
UniProt Comments for SERPINC1
Function: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.

Subcellular location: Secreted › extracellular space.

Tissue specificity: Found in plasma. Ref.21

Post-translational modification: Phosphorylation sites are present in the extracelllular medium.

Involvement in disease: Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [

MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Ref.3 Ref.12 Ref.13 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35 Ref.36 Ref.37 Ref.38 Ref.40 Ref.41 Ref.42 Ref.43 Ref.44 Ref.45 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.51 Ref.52 Ref.53 Ref.54 Ref.55 Ref.56 Ref.57 Ref.59 Ref.60 Ref.61 Ref.62 Ref.63 Ref.64 Ref.65 Ref.66

Sequence similarities: Belongs to the serpin family.

Mass spectrometry: Molecular mass is 57863 Da from positions 33 - 464. Determined by ESI. Ref.13Molecular mass is 57911 Da from positions 33 - 464. Determined by ESI. Variant Thr-414. Ref.13
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withSERPINC1 native protein
 Reference Product  PubMed Publications
 PLG native protein  >1 publications with SERPINC1 and PLG
Organs/Tissues associated with SERPINC1 native protein
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