• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

SERPING1 protein :: C-1 Esterase Inhibitor, Human Plasma Protein

Scan QR to view Datasheet
Catalog # MBS135776
Unit / Price
Scan QR to view Datasheet
DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Testing Data
Product Name

C-1 Esterase Inhibitor, Human Plasma (SERPING1), Protein

Popular Item
Full Product Name

C-1 Esterase Inhibitor, Human Plasma

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (57365027..57382326). Location: 11q12.1
OMIM
106100
3D Structure
ModBase 3D Structure for P05155
Host
Human plasma
Purity/Purification
>95% by SDS-PAGE analysis
Form/Format
Frozen liquid
Concentration
2.0 mg/ml (lot specific)
Buffer
0.02M Potassium Phosphate; 0.25M NaCl; pH 7.0
Extinction Coefficient
0.4
Preparation and Storage
Store at -70 degree C. Shelf Life: 3 years from delivery
Shipping: Ships with Dry Ice.
Other Notes
Small volumes of SERPING1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SERPING1 protein
A single chain glycoprotein which inhibits C1, C1r, C1s, plasma kallikrein, Factors XIa. XIIa, and plasmin. Present in plasma at 16-33 mg per 100 ml. C1 esterase inhibitor deficiency is a rare condition resulting in facial swelling and abdominal cramping. Usually the condition is hereditary , though it may also occur when the C1EI is non-functional. Prepared from plasma shown to be nn reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV1 & 2 by FDA approved tests. > 95% pure by SDS-PAGE

Testing Data of SERPING1 protein
SERPING1 protein Testing Data image
NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
100,000
NCBI Official Full Name
plasma protease C1 inhibitor
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
NCBI Official Symbol
SERPING1  [Similar Products]
NCBI Official Synonym Symbols
C1IN; C1NH; HAE1; HAE2; C1INH
  [Similar Products]
NCBI Protein Information
plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1
UniProt Protein Name
Plasma protease C1 inhibitor
UniProt Synonym Protein Names
C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
UniProt Gene Name
SERPING1  [Similar Products]
UniProt Synonym Gene Names
C1IN; C1NH; C1 Inh; C1Inh  [Similar Products]
UniProt Entry Name
IC1_HUMAN
NCBI Summary for SERPING1
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
UniProt Comments for SERPING1
SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; aging

Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000