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SERPING1 protein :: C-1 Esterase Inhibitor, Human Plasma Protein

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Catalog # MBS135776
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Testing Data
Product Name

C-1 Esterase Inhibitor, Human Plasma (SERPING1), Protein

Popular Item
Full Product Name

C-1 Esterase Inhibitor, Human Plasma

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (57365027..57382326). Location: 11q12.1
3D Structure
ModBase 3D Structure for P05155
Human plasma
>95% by SDS-PAGE analysis
Frozen liquid
2.0 mg/ml (lot specific)
0.02M Potassium Phosphate; 0.25M NaCl; pH 7.0
Extinction Coefficient
Preparation and Storage
Store at -70 degree C. Shelf Life: 3 years from delivery
Shipping: Ships with Dry Ice.
Other Notes
Small volumes of SERPING1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
SERPING1 protein
A single chain glycoprotein which inhibits C1, C1r, C1s, plasma kallikrein, Factors XIa. XIIa, and plasmin. Present in plasma at 16-33 mg per 100 ml. C1 esterase inhibitor deficiency is a rare condition resulting in facial swelling and abdominal cramping. Usually the condition is hereditary , though it may also occur when the C1EI is non-functional. Prepared from plasma shown to be nn reactive for HbsAG, anti-HCV, anti-HBc, and negative for anti-HIV1 & 2 by FDA approved tests. > 95% pure by SDS-PAGE

Testing Data of SERPING1 protein
SERPING1 protein Testing Data image
NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
plasma protease C1 inhibitor
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
NCBI Official Symbol
SERPING1  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1
UniProt Protein Name
Plasma protease C1 inhibitor
UniProt Synonym Protein Names
C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
UniProt Gene Name
SERPING1  [Similar Products]
UniProt Synonym Gene Names
C1IN; C1NH; C1 Inh; C1Inh  [Similar Products]
UniProt Entry Name
NCBI Summary for SERPING1
This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]
UniProt Comments for SERPING1
SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; aging

Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of
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